DescriptionAbout the RoleBCRF is seeking a founding Managing Director (MD) - an exceptional individual who will build and lead the Venture Philanthropy Program from the ground up. This is a rare opportunity to shape a mission-driven investment program that will directly influence the pace of breast cancer drug, diagnostic, and prevention technology development globally, backed by the credibility and scientific network of the world's largest private funder of breast cancer research.
At $100 million, the Program is sized not merely to catalyze individual discoveries, but to reshape the early-stage breast cancer investment ecosystem. The Program will build a diversified portfolio of 20 to 30 companies over five to seven years, with BCRF moving from participant to lead investor: structuring deals, convening co-investment syndicates, and negotiating mission-protection covenants alongside leading oncology venture capital firms.
"The Program will exhibit the discipline of venture capital, and the patience and purpose of philanthropy. The Managing Director will be the embodiment of both."
The MD will serve as the Program's chief investment officer and primary operational executive, responsible for the full investment lifecycle - strategy, sourcing, scientific and business evaluation, deal structuring, Investment Committee management, portfolio oversight, and performance reporting - and will build the Program's founding team, including an Investment Principal, Operations Manager, and Associate over the course of Year 1. The MD will also serve as the Program's primary external representative to the venture capital and biopharmaceutical communities, and as a senior ambassador for BCRF's mission to donors, scientific collaborators, and the broader breast cancer community.
The ideal candidate will bring a distinctive combination of deep scientific and clinical knowledge of oncology - ideally breast cancer - and demonstrated investment experience in early-stage biotechnology. This dual expertise is the defining requirement of the role: the Program must evaluate the scientific and clinical merit of investment opportunities as its primary objective, while maintaining the financial discipline expected for a nonprofit mission program.
BCRF's offices are in New York. While candidates based in the New York Metro area are preferred, BCRF is open to locating the Venture Philanthropy Program in the Boston, Massachusetts area and will consider exceptional candidates from the greater Boston area for this position. BCRF currently requires staff to work onsite a minimum of three days per week, and this requirement will apply to the Venture Philanthropy team.
Primary ResponsibilitiesReporting to the BCRF President & Chief Executive Officer and working in close partnership with the Program's Investment Committee, the Managing Director will be accountable for the full operating lifecycle of the BCRF Venture Philanthropy Program.
Investment Strategy and Execution
- Develop, refine, and implement the Program's investment strategy, ensuring consistency with BCRF's mission and the Investment Thesis.
- Lead all aspects of deal sourcing, scientific and business due diligence, term sheet negotiation, investment structuring, and closing across all three investment tiers.
- Build and maintain a high-quality pipeline of 100-120 annual investment opportunities, managing the funnel from initial intake through Investment Committee review and approval.
- Prepare comprehensive investment memoranda and present investment recommendations to the Investment Committee.
- Assume Board observer roles at portfolio companies on behalf of BCRF Ventures, LLC.
- Evaluate and recommend follow-on investments in portfolio companies based on milestone achievement and evolving strategic rationale.
Scientific and Clinical Leadership
- Serve as the Program's primary scientific and clinical intelligence resource, maintaining current, expert-level knowledge of the breast cancer research landscape across subtypes (TNBC, HER2+, HER2-low, HR+, inflammatory, metastatic).
- Evaluate the scientific and clinical merit of investment candidates, including mechanism of action, preclinical and clinical data packages, biomarker strategies, regulatory pathway feasibility, and competitive differentiation.
- Engage and manage external scientific and clinical Key Opinion Leaders who provide independent expert review during due diligence.
- Maintain active relationships with BCRF's 265+ investigator network and leverage scientific intelligence from that network to identify emerging translational opportunities.
Portfolio Management
- Actively monitor portfolio company progress against milestones defined in investment documentation; prepare quarterly portfolio status reports for the Investment Committee.
- Provide strategic advisory support to portfolio companies on clinical development strategy, regulatory planning, partnership development, and financing.
- Identify and escalate material risks in portfolio companies - scientific, clinical, regulatory, competitive, or managerial - and recommend remediation strategies.
- Manage the Program's follow-on investment reserve and advise the Investment Committee on redeployment priorities.
Investment Committee and Governance
- Coordinate all aspects of Investment Committee meeting preparation: agendas, investment packages, portfolio reports, and follow-on analyses; serve as IC Secretary.
- Ensure the Program operates in full compliance with BCRF's governance policies, conflict-of-interest procedures, PRI legal requirements, and BCRF's broader Code of Ethics.
- Support PRI qualification analysis for each investment structure.
- Prepare the annual Program report to the full BCRF Board of Directors.
External Representation and Ecosystem Development
- Represent BCRF and the Program at key industry and scientific conferences, including ASCO, AACR, SABCS, the JP Morgan Healthcare Conference, and BIO.
- Build and maintain active relationships with life science venture capital firms, corporate VC programs, biotechnology business development leaders, academic technology transfer offices, and SBIR/STTR program officers to sustain high-quality deal flow.
- Partner with BCRF's development team to integrate the Program's impact narrative into BCRF's donor communications and fundraising strategy, and represent the Program to major philanthropic supporters. Develop progress reports for the Board of Directors and key donors.
Team Building and Culture
- Recruit, mentor, and develop Program staff as the portfolio grows - including the founding Investment Principal, Operations Manager, and Associate.
- Build a culture of scientific excellence, investment rigor, and mission commitment within the Program team.
About YouThe Managing Director will be a highly distinguished professional whose career reflects excellence at the intersection of oncology science, clinical development, and early-stage biotechnology investment. While BCRF's Program is fundamentally a scientific enterprise focused on delivering new diagnostics and therapies to breast cancer patients, it must be administered with the financial discipline expected in a nonprofit organization.
The successful candidate will most likely have built their career across two or more of the following domains: life science venture capital or corporate venture capital; pharmaceutical or biotechnology drug development; oncology clinical or translational research; or biotech business development and licensing. Candidates with a single domain of deep expertise - whether investment or science - who have not developed meaningful fluency in the other will not be considered.
In addition, you have the following qualifications and experience:
- Minimum 10 years of combined experience in life science investment and/or oncology drug or diagnostic development, with at least 5 years in a senior investment role (Principal, Partner, Managing Director, or equivalent) at a life science venture capital, corporate venture capital, growth equity, or cross-over fund.
- An advanced degree is required, ideally an MD, PhD and/or MBA.
- Demonstrated track record of sourcing, evaluating, structuring, and closing equity investments in early-stage oncology or broader biopharmaceutical companies.
- Deep scientific and clinical knowledge of oncology, with a strong preference for direct experience in breast cancer therapeutics, breast cancer diagnostics, or an adjacent solid tumor or women's health indication.
- Expert-level understanding of drug and diagnostic development processes: target identification and validation, IND-enabling studies, Phase I/II clinical trial design, biomarker strategy, FDA regulatory pathways (including Breakthrough Therapy, Fast Track, Accelerated Approval), and commercialization planning.
- Experience evaluating and conducting due diligence on oncology drug candidates, including critical assessment of preclinical data packages, clinical trial data, competitive landscape analysis, and IP position.
- Familiarity with investment structures used in early-stage biotech: preferred equity, convertible notes, royalty-backed financing, milestone-linked instruments, and co-investment syndication.
- Proven ability to build and maintain trusted relationships with biotechnology founders and management teams, venture capitalists, pharmaceutical business development executives, and academic scientists.
- Excellent written and verbal communication skills, including the ability to convey complex scientific and investment concepts to non-specialist audiences including board members, major donors, patient advocates and the media.
Strongly Preferred Experience- Direct experience with breast cancer biology and/or clinical oncology - including knowledge of breast cancer molecular subtypes (HR+/HER2-, HER2+, TNBC, HER2-low), current standards of care, approved and pipeline therapies, and unmet clinical needs across the disease spectrum.
- Prior experience at, or in close collaboration with, a disease-focused nonprofit venture philanthropy program (e.g., the T1D Fund, LLS TAP, ACS BrightEdge, Cystic Fibrosis Foundation, Lupus Ventures).
- Board or Board observer experience at early-stage private biotechnology companies.
- Experience with Program-Related Investments (PRIs), nonprofit investment governance, or nonprofit legal compliance.
- Established relationships within the breast cancer biotech and academic research ecosystem - NCI-designated Cancer Centers, leading oncology academic medical centers, and breast cancer-focused investors.
- Experience with diagnostics and companion diagnostic development, in addition to therapeutics.
Compensation and BenefitsThis is a full-time exempt position. The compensation package for this role consists of a base salary of $450,00 - 475,000 annually and eligibility for up to a 20% bonus dependent on the incumbent's performance against mission impact metrics and stated programmatic goals.
Our compensation package also includes an exceptional benefits package focusing on employee physical, mental and financial wellness. More specifically we offer
- Medical, dental and vision coverage from the first day of employment; with the election of certain medical plans, BCRF helps significantly defray the cost of out-of-pocket expenses with contributions to a health reimbursement account or heath savings account.
- The opportunity to enroll in pre-tax Commuter Transit, Flexible Spending Account or Health Savings Account and Dependent Care Account from the first day of employment.
- 401K, with up to a 5% match each pay period; employee contributions and any match are immediately fully vested
- Paid parental leave offering 18 weeks 100% paid leave for a birthing parent and 12 weeks 100% paid leave for non-birthing parent
- Paid Time Off including
- 15 days of annual vacation time in first year of employment, increasing with length of service
- 7 days of annual paid sick time
- Paid holidays along with BCRF wide half days and summer Fridays
To ApplyPlease submit a resume and cover letter expressing your intention to apply for the role
