PhD in cell biology, bioengineering, cancer biology, or related field; or MS with 4+ years of relevant research experience.
Knowledge of renal, pancreatic, lung, or colon biology.
Proficient in molecular biology techniques including immunofluorescence (IF), immunohistochemistry (IHC), western blotting, and flow cytometry.
Experience with advanced microscopy techniques such as confocal and high-content imaging.
Strong verbal and written communication skills.
Responsibilities
Establish and maintain organoid cultures while optimizing protocols for improvement.
Develop and troubleshoot complex co-culture systems integrating various human cells.
Create novel in vitro assays using advanced modeling techniques to support oncology research.
Design and execute high-throughput assays for molecule screening using microscopy.
Perform 3D cell culture assays measuring viability and drug responses.
Benefits
Innovative lab environment working on cutting-edge oncology research.
Opportunity for independent project development and optimization.
Collaboration with multidisciplinary teams.
Flexible and adaptable work culture.
Support for professional growth and learning opportunities.
Full Job Description
We currently have a role available for an Expert In Vitro Biologist.
Job duties include, but are not limited to, the following:
Establish, expand, and maintain patient-derived and tissue-specific organoid cultures. Independently optimize protocols for improved fidelity, maturation, and biological relevance.
Independently develop, troubleshoot, and improve complex co-culture model systems incorporating primary human tumor cells, fibroblasts, immune cells, and microenvironment components to deliver robust scientific answers.
Establish and optimize novel in vitro assays using 3D organotypic models, complex co-cultures, organoids, transwell systems, air-liquid interface, and/or organ-on-a-chip platforms representing both healthy and disease states to support discovery oncology programs.
Design and execute semi- or high-throughput endpoint and kinetic assays for safety and efficacy screening of molecules during early discovery using advanced microscopy.
Perform 3D cell culture assays, including viability, proliferation, differentiation, and drug response studies, using cellular and molecular biology techniques such as CellTiter-Glo, Western blotting, ELISA, flow cytometry, and immunofluorescence staining.
Job requirements include, but are not limited to:
PhD in cell biology, bioengineering, cancer biology, or a related discipline; or MS in a related field with 4+ years of relevant research experience.
Working knowledge of at least one of the focus areas: renal, pancreatic, lung, or colon biology.
Experience with molecular biology techniques such as IF, IHC, western blotting, and flow cytometry.
Experience with advanced microscopy techniques (confocal, light sheet, high-content imaging) for assessing the phenotype of complex models and kinetic assays.
Excellent communication skills - verbal and written.
Works well both as a team and as an individual.
Demonstration of excellent team player skills, very strong attention to detail, very strong problem-solving skills, a high level of learning agility, and the ability to work across functions. The ideal candidate will be enthusiastic and self-motivated, with the leadership and communication skills necessary to operate effectively in a fast-paced multidisciplinary environment with flexibility and an adaptable approach to goal delivery.
This is a day shift position (approx. 8a-5p local time).
