Executive Medical Director, Global Medical (Nephrology)

Job Description

General Summary:

The Executive Medical Director, Global Medical Lead (GML), Nephrology is a critical leadership role in Global Medical,responsible for the global medical strategyand implementationand trackingofglobal activities fora designateddisease area(s).Key accountabilities include, but are not limited to,diseaseareaspecificIntegratedMedical Plan development,includingthepublication plan,integrated evidence generation plan, globalmedical launch strategyand execution, scientific leadership, external medical expert engagement, and strategicalignmentwith commercial and other cross-functional business partners.. This leader reports directly to the VP, GlobalMedicaland is a core member of the Global Medical leadership team.They will lead theglobal medical affairs team for the designated disease area(s) andrepresentsMedical Affairs in all Global strategicteamswithDevelopment and Commercial, including the Disease Strategy Team (DST)to drive cross-functional alignment,anticipatefuture needs, and contribute toMedical Affairsand Vertex
9s long-term success.

Key Duties and Responsibilities:

Medical Strategy

• Leadthedevelopment,implementation,execution, and communication of theIntegrated Medical Plans,includingbut not limited tomedical strategy,global tactical plan,publication,congressandevidence generationplans,in collaboration with Clinical Development, Clinical Operations, HEOR, RWE, Medical Writing, and other internal stakeholders across Vertex

• Ensure alignment of medical strategy with organizationalobjectivesby integrating individualand disease area team goalswith Vertex and DST priorities,and the goals of cross-functional partners

• Expertlydistillsinsightsand actionable outcomesthatinformstrategy anddrive the greatest impact for Medical Affairs

• Establishes and tracks medical KPIs thatdemonstrateimpact on asset strategy and patient outcomes.

• Applies structured problem-solving and root cause analysis toidentifysolutionsand make decisionsthat maximize medical and asset strategy impact

• Able toidentifywhat is important and impactful to medical and the wider organization,prioritize competing demandsand communication to key stakeholders

• Accountablefor development of theglobalDA budget, management of funds allocation, and associated tracking to ensure alignment with Medical Affairs priorities andefficient resource allocation

Scientific Excellence

• Serve as product and disease area expert and Global Medical primary contact point for all globaldisease area related issues with the external community and internally at Vertex

• Able toleaddevelopment of peer reviewed publications, congresspresentationsand evidence generation to inform clinical practice

• Lead the development of global scientific communications and materials including materials for globalledsymposia, advisory boards, and training.

• Accountable for medical review of assigned brand related contentand global medical content aligned with Vertex SOPs

External Partnerships

• Represent Vertex at scientific and medical forums, including medical education forums, scientific societies, patient advocacy groups, and congresses.

• Accountable for engaging and cultivating professional relationships with leading global key thought leaders (TL) to gain greater understanding of thediseasearea, and insights into unmet patient needs

Medical Communication

• Tailorscommunicationto stakeholder needs, building trust and understanding across diverse audiences.

• Deliver external presentations (advisory board meetings, symposia, other medical education meetings) to enhance the medical knowledge of pipeline and marketed products, asrequiredandin accordance withrelevant regulations and procedures

• Support disease area training across the company asrequired

• Responsible for medical interpretation of data (clinical trials, registries, published literature, etc.) forpipeline therapies andmarketed medicines

RegionalMedicaland Cross FunctionalCollaboration

• Accountable for the medical component of the go to market model Inabsenceofregionsteams,medical components of the countrygo to market modelremainsthe responsibility ofthe GML.

• Support regional Medical Affairs and Medical Excellence teams fromlaunchthrough lifecycle viatimelydelivery of fit-for-purpose training and core materials.

• Responsible for driving alignment on medical content/messaging within the organization to ensure maximalfunctionaland regional input.

• Medical Affairsleaderon key global cross-functional product and development strategic focused teams,including DST and relevantsub teams

• Effectivelyrepresentsand communicates DST priorities to the medical function and proactively communicates andrepresentsmedical needs to DST

• Chair the Global Medical Area Team (GMAT) for the diseaseareaand accountable for deliverables

• Provide strategicMedical Affairsleadershipon relevant commercial teams: Launch Team, and Global brand teams for product

• RepresentMedical Affairs in label discussions

• Support Access, Patient Advocacy, Policy, and Corporate Communications teams with medical/scientificexpertiseand materials review.

Evidence Generation and Access

• Accountable for the strategy,developmentand execution ofLife Cycle Management studies in partnership with HEOR, includingIntegratedEvidence Generation plan in close collaboration withkey internal stakeholders

• May act as medical monitor for studies falling under the Medical Affairs scope in collaboration with Clinical Development, Real World Evidence, Health Economics and Outcomes Research, and Clinical Operations

• Lead oversight and management of ISS programs, and in collaboration with Regional Medical leadership, conduct critical scientific and medical review of ISS protocols

• As applicable, lead Managed Access Committee for assets with a Managed Access Program (MAP); may act as a Medical Monitor for MAP

Team/People Management

• Provide strong leadership todedicateddisease areamedicalteam, inspiringand empoweringa dedicated medical team,and promoting a culture of continuous development.

• Accountable for therecruitment, development, management and coaching theDA globalmedical team

• Leverages the capabilities andexpertiseof the team to ensure successful execution of medical plans

• Identifiesand addresses team skill gaps, considering how to accelerate internal talent or attract external to meetneedsof a future-ready organization.

• Adheres toformalgoal-setting,talent and performance cycles ensuringindividual development plans (IDPs)are in place

• Navigates ambiguous or rapidly evolving situations, andcoachthe team during periods of uncertainty or change.

Compliance and Pharmacovigilance:

• Ensure complianceofmedical activities according to global and regionalguidelines andin accordance withVertexCode of Conduct, rules and regulations, company policies, SOPs, GCP and ICH

• Ensure self and othermedicalcolleagueshave the required skills toidentifyand report AEsappropriately

• Contribute to managing external communication when significant safety issues arise, with the wellbeing of patients being theultimate goal

Education and Experience:

• MD (preferred), PhD, PharmD or other advanced life sciences degree required
• Typically requires 10 years of experience and 5 years of supervisory/management experience or the equivalent combination of education and experience
• 6 or more years of relevant leadership experience in medical affairs and/or clinical development, including experience in both Global and Country/Region desired
• 2 or more years of industry experience in disease areaor 2 or more years of clinical / academic experience in disease area

Pay Range:

$328,000 - $492,000

Disclosure Statement:

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1.Hybrid: work remotely up to two days per week; or select
2.On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex
9s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid