Leads chemical engineering strategy and execution oversight to ensure DS/DP processes are scalable, safe, and transferable to external manufacturing. Defines equipment/process suitability expectations, drives process safety and manufacturability assessments, and supports resolution of scale-up constraints. Ensures engineering inputs align with validation strategy and sustained performance post-transfer, enabling reliable supply execution.
Key Responsibilities- Set engineering standards for scale-up readiness, safety, and process/equipment fit
- Support DS/DP teams in defining scalable process parameters and operating ranges
- Lead engineering input to tech transfer, process safety reviews, and risk assessments
- Drive yield/throughput/cycle-time improvement opportunities with external partners
- Ensure engineering documentation supports validation readiness and audit expectations
Required Qualifications- BS+ in Chemical Engineering (advanced degree preferred)
- 18+ years in process/chemical engineering supporting GMP manufacturing/tech transfer
- Demonstrated leadership in scale-up, safety, and external manufacturing collaboration
- Strong cross-functional influence and structured problem solving
Preferred Qualifications- Experience supporting SDD process scale-up and solvent/safety considerations
- Experience supporting validation/PPQ readiness activities
Key Competencies- Scale-up engineering, process safety, and manufacturability
- Tech transfer readiness and constraint resolution
- Continuous improvement and performance-focused execution
- Documentation rigor and stakeholder communication
Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate's qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $276,205 - $328,644 per year. We comply with all applicable minimum wage laws.
All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.
