Overview Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa's lead investigational candidate - cleminorexton (formerly ORX750) - is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a
Great Place to Work® in 2026.
The Director, External Quality Control & Stability will provide leadership and oversight for analytical testing, stability programs, specification management, and quality control activities supporting clinical and commercial development.
ResponsibilitiesAnalytical Oversight and Tactical Support - Develop and Lead analytical quality control strategy across multiple programs.
- Review analytical methods, specifications, and validation activities for adequacy and collaborate on updates, as required.
- Support analytical method transfer, as required
- Collaborate on supplier qualification and/or remediation activities.
Stability Program Leadership- Oversee the stability program design and execution across multiple programs.
- Monitor and report on stability trends and product quality attributes as required.
- Ensure ongoing regulatory compliance of stability activities.
Supplier Oversight- Manage supplier ongoing relationships.
- Perform routine reviews of testing results and overall quality of documentation.
- Drive issue resolution to facilitate regulatory compliance.
Regulatory Support- Provide tactical support for regulatory submissions
- Support health authority inspections and audits, as required.
- Review analytical and stability sections within CMC filings.
Basic Qualifications- BS/MS/PhD in Chemistry, Analytical Chemistry, Pharmaceutical Sciences, or related field.
- 10+ years quality control and analytical development experience.
- Experience developing strategic vision as well as providing tactical support for quality control programs
Work LocationThe Director, External Quality Control & Stability role is a remote role based in the US.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$117,000 - $259,600
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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