Role Summary:The Director, Clinical Practice Liaison (CPL) is a senior leadership role with broader strategic accountability for the CPL function (part of the Field Medical Team at Madrigal) within a defined U.S. region and therapeutic area. This individual will play a pivotal role in shaping the vision, direction, and performance of the CPL team, ensuring the team aligns with and advances the company's overarching medical strategy, adheres to regulatory and internal policies, and maximizes scientific impact for both internal and external stakeholders.
This position will collaborate closely and compliantly with cross-functional colleagues (e.g., Marketing, Sales, Market Access, Clinical Operations, HQ Medical Affairs) and external partners, including healthcare decision-makers and other relevant stakeholders, serving as a key liaison to drive strategic initiatives and influence medical and business outcomes.
The position reports to the Executive Director, Field Medical and is a field-based position with travel required within assigned territory.
All incumbents are responsible for following applicable Medical Affairs & Madrigal policies and procedures and are compliant with applicable policies, procedures, and regulations. Strong understanding of US regulations and compliance is required.
Please note: Candidates may reside anywhere within the Eastern United States.
Key Responsibilities and Primary Activities: - CPL Team Scientific & Clinical Education
- Support and help shape the regional strategy for the CPL team to deliver unbiased, evidence-based education on MASH, ensuring CPLs address identified gaps in knowledge and clinical implementation
- Promote consistent and high-quality communication of clinical practice guidelines and real-world data related to MASH diagnosis, risk stratification, and patient management
- Maintain strong working knowledge of MASH Non-Invasive Testing (NITs), treatment paradigms, and clinical protocols across the liver/metabolic spectrum, while providing scientific guidance to the team
- CPL Team Practice Engagement & Enablement
- Support the Executive Director in the oversight of practice engagement, ensuring CPLs effectively support implementation of MASH care pathways
- Support adoption of guideline-based approaches, payer-aligned workflows, and quality-driven practice standards across the region.
- Ensure accuracy and compliance in CPL responses to unsolicited inquiries, reinforcing regulatory expectations
- Team Leadership & Development
- Recruit, coach, and manage performance of regional CPLs
- Foster continuous development through mentoring, structured training, and scientific upskilling
- Ensure CPL activities align with strategic objectives and tactical plans, supporting consistency and quality in execution
- Medical Strategy Execution
- Execute regional field medical strategies in alignment with national direction
- Translate national medical objectives into actionable, regionally tailored field activities
- Partner with HQ Medical Affairs and cross-functional leaders to integrate meaningful field insights into medical planning
- Collaborate with Clinical Operations to support successful study execution based on regional site and practice needs
- Identify potential research sites or practice barriers informed by field insights
- Cross-Functional Collaboration
- Act as a regional medical point-of-contact, partnering across Medical Affairs, Sales, Marketing, Market Access, and Clinical Operations to maintain alignment and address clinical or strategic needs
- Serve as a conduit for HQ Medical Affairs initiatives, ensuring clear communication and coordinated execution
- Contribute to launch readiness and lifecycle management activities, ensuring CPL efforts support national and regional priorities
- Represent Madrigal at scientific meetings, supporting CPL engagement and ensuring compliant scientific exchange and insight collection
- Insight Gathering & Strategic Feedback
- Synthesize, prioritize, and elevate regionally derived insights to inform medical strategy, evidence-generation planning, and educational needs
- Keep abreast of regional analysis of emerging clinical trends and barriers to care, providing strategic recommendations for internal planning
- Ensure structured, compliant insight reporting across the CPL team
- Compliance & Professional Standards
- Adhere strictly to all applicable company and regulatory policies, including FDA and industry guidelines for non-promotional medical engagements
- Ensure thorough documentation and accountability for all scientific interactions.
- Maintain a strong understanding of US regulations and compliance
- Ability to travel from 25-70% including support of scientific meetings over weekends
Required Qualifications, Skills & Experience:- Advanced degree in a scientific or healthcare discipline (MD, PharmD, PhD, DNP, etc.)
- Minimum 5 years of Medical Affairs experience, including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)
- Minimum 3 years of people management experience or formal leadership development participation
- In-depth knowledge of clinical medicine and medical research
- Proven ability to understand, communicate, and translate complex scientific information
- Strong knowledge of U.S. healthcare system, FDA regulations, and medical affairs compliance standards
- Demonstrated cross-functional collaboration, project execution, and strategic planning skills
- Proficiency in Microsoft Office Suite, virtual communication platforms (e.g., Zoom, Teams), and related Medical Affairs Systems (e.g. Veeva Vault, CRM tools)
Preferred Attributes:- In-depth knowledge of liver disease; experience in cardiometabolic health, or endocrinology/metabolic disease
- Strong interpersonal, presentation, and relationship-building skills
- Adaptable and proactive in a fast-paced, evolving environment
- Passion for mentoring, team building, and field-based medical innovation
#LI-Remote
Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate's qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $233,134 - $267,100 per year.
All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.
