Fluency in clinical imaging regulations and technical data interpretation
Proven experience with human brain MRI data processing using neuroimaging software
Experience managing imaging vendors and CROs with budget oversight
Strong communication and presentation skills
Responsibilities
Design imaging plans for clinical trials using advanced imaging technology and disease knowledge
Communicate strategies and decisions to stakeholders and governing bodies
Oversee brain MRI processing and data analysis for clinical trials
Lead cross-functional alignment with departments like Research and Clinical Operations
Manage resources for seamless program execution
Collaborate with Preclinical and Translational Imaging teams
Contribute to imaging-related documentation development
Benefits
Collaborative working environment focused on fundamental discovery research
Opportunity to lead innovative imaging biomarker programs
Engagement with diverse therapeutic areas targeting aging and age-related diseases
Potential for professional growth through research partnerships
Involvement in cutting-edge imaging technology and methodologies
Full Job Description
Position Description:
We are looking for an experienced and innovative Director of Clinical Imaging to lead the strategic planning, development, and execution of imaging biomarker programs to ensure alignment with our diverse therapeutic pipeline targeting aging and age-related diseases. This role will oversee the strategy, implementation, and resource allocation for all clinical imaging science activities, ensuring the successful delivery and interpretation of imaging biomarkers for the evaluation of novel therapeutic drug candidates.
The ideal candidate will have a deep understanding of drug discovery and development, experience with various imaging modalities, and a track record of managing internal teams and external partners in the integration of quantitative human imaging into the clinical portfolio across all phases. Calico provides a stimulating and collaborative working environment focused on fundamental discovery research and a commitment to translate scientific advances to realize their therapeutic potential. Responsibilities:
Imaging Strategy and Execution:
Design tailored imaging plans for early-to-late-phase clinical trials by leveraging your understanding of clinical imaging technology, image processing techniques, and disease pathology
Effectively communicate strategies and key decisions to internal and external stakeholders and corporate governing bodies
Oversee and/or execute brain MRI processing and data analysis for clinical trial data and clinical research databases to develop and validate imaging biomarkers
Cross-functional Collaboration:
Serve as the functional lead responsible for cross-functional alignment with other departments, including Research, Clinical Science, Clinical Operations, Biomarkers, Biometrics, and Regulatory Affairs
Manage resources to ensure seamless program execution across the portfolio
Collaborate with Preclinical and Translational Imaging teams to translate insights into clinical programs
Team Leadership:
Provide scientific and strategic leadership as needed for clinical imaging, including oversight of relevant internal teams and external partners such as vendors and collaborators
Regulatory and Clinical Documentation:
Contribute to the development and standardization of imaging-related documentation, including clinical protocols, regulatory documents, imaging manuals, and image analysis charters
Research Partnerships:
Identify, establish, and manage collaborations with academic institutions and internal research and computing groups to explore novel imaging databases and methodologies
Position Requirements:
Ph.D. degree in Physics, Biomedical Engineering, Computer Science, or related field
A minimum of 10 years of experience in drug development with a focus on human imaging biomarker development
In-depth knowledge of at least one, and preferably multiple imaging modalities (e.g., PET, SPECT, MRI, CT, Ultrasound) and their application in drug development
Technical and regulatory fluency in clinical imaging, coupled with demonstrable experience translating technical data into clear, strategic development recommendations
Proven expertise in human brain MRI data handling and processing across diverse clinical scanner platforms, utilizing neuroimaging processing software and libraries (e.g., FreeSurfer, FSL, SPM, ANTs, MRtrix3, AFNI)
Scientific understanding of therapeutic areas relevant to Calico (neuroscience, nephrology, oncology, rheumatology) is preferred
Experience in managing imaging vendors and CROs and management of associated budgets
Self-motivated and flexible with a "can-do" attitude
Strong communication and presentation skills
Must be willing to work onsite four days a week
Nice to Have:
Demonstrated track record implementing and validating AI/ML frameworks applied to brain MRI tasks such as automated lesion segmentation, regional parcellation, pattern classification, or image reconstruction
Proficiency in scientific programming languages and familiarity with neuroimaging standards (DICOM, NIfTI)
Experience with cloud computing platforms and containerization (Docker, Singularity)
The estimated base salary range for this role is $280,000 - $285,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
