BS with 5+ years or MS with 2+ years of relevant research experience in life sciences or related fields
Experience with automated liquid handling systems and high-throughput workflows
Familiarity with automating cell-based screening workflows; flow cytometry experience is a plus
Proficiency in nucleic acid QC methods like TapeStation and qPCR
Hands-on molecular biology experience, including cloning and RNA production
Working knowledge of data analysis tools such as Excel and GraphPad Prism
Strong organizational skills for managing large sample sets and overlapping projects
Responsibilities
Develop automation capabilities for reagent generation and high-throughput screening
Optimize automated workflows for plasmid cloning and RNA generation
Run QC assays to verify plasmid constructs and assess IVT product integrity
Partner with scientists to automate plate preparation and assay setup
Coordinate DNA synthesis and reagent orders with vendors
Manage inventories of raw materials, plasmids, and RNA
Maintain detailed documentation in electronic lab notebooks
Present findings and contribute to scientific discussions
Benefits
Collaborative and innovative work environment
Opportunity to work on cutting-edge gene editing technologies
Engagement with diverse R&D teams
Focus on professional development and scientific impact
Access to advanced laboratory equipment and resources
Full Job Description
About the Role:
Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team and build automation capabilities that accelerate the development of our next-generation gene editing tools. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. This individual will play a key role in discovery and engineering efforts, advancing recombinase-based genome editing platforms and collaborating across diverse R&D teams.
Key Responsibilities & Accountabilities:
Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows
Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT)
Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products
Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens
Coordinate DNA synthesis and reagent orders with external vendors
Manage raw material, plasmid, and RNA inventories
Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks
Present findings clearly to other teams and contribute to scientific discussions and decision-making
Qualifications & Skills:
BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field
Experience with automated liquid handling systems (e.g., Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting
Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus
Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
Hands-on molecular biology experience, including cloning and RNA production and purification
Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling
Experience with laboratory inventory management
Track record of generating precise, reproducible data and performing rigorous quantitative analysis
Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences
Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects
Strategic thinker who effectively plans and prioritizes to maximize scientific impact
Collaborative mindset with a team-first attitude
Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty
