Your impact The experienced Associate Director of Translational Medicine will lead, own and execute the Translational Medicine strategy for Isomorphic's oncology portfolio. Reporting to the Head of Translational Medicine, this is an opportunity for an innovative leader to play a foundational role in shaping and advancing oncology programs through clinical proof of concept. They will leverage AI and emerging technologies to ensure efficient outcomes with a high probability of success.
What you will do - Lead and execute the Translational Medicine strategyacross oncology programs. Ensure readiness of clinical biomarker assays and delivery of corresponding data to address mechanism of action, predictive and prognostic insights, mechanisms of drug resistance and to inform future indications and combinations.
- Serve as a core member of the oncology program teams and subject matter expert for cancer biology. Collaborate with cross-functional teams to set the program strategy and clinical trial design across tumor types and drug modalities.
- Deliver clinically validated assays and advance companion diagnostic development for biomarker selected studies.
- Work closely with the early portfolio scientific teams to ensure clinical input is incorporated at the start of the drug development process, and preclinical insights are translated into the clinical design
- Collaborate with AI and Computational Biology teams to identify, create and utilize innovative tools for analysis of biomarker and translational datasets, accelerate diagnostic advances and explore new approach methodologies (NAMs).
- Serve as a key contributor to the translational sections of clinical and regulatory documents including INDs, IBs, clinical protocols, lab manuals, and briefing books.
- Collaborate across internal and external stakeholders to represent and communicate the translational strategy.
- Oversee and manage external CROs to ensure on time and robust data delivery
Skills and qualifications Essential:- Ph.D. or similar in biology or related field
- 7+ years of translational experience within biotech or pharma including oncology.
- Proven success implementing and executing translational strategy, clinical biomarkers and diagnostic development in oncology studies.
- Experience working cross-functionally with key stakeholders internally as well as external vendors and collaborators.
- Significant expertise in cancer biology and drug development
- Strong appetite to work in an AI-first environment.
- Willingness to go beyond traditional assays and approaches, incorporating cutting edge methodologies that may enhance therapeutic probability of success and velocity.
- Sense of urgency and accountability to operate in a fast-paced environment.
- Flexibility to adapt to changing timelines and priorities.
- Strong leadership and excellent communication skills.
Nice to have:- Experience working on global oncology studies across multiple clinical phases, tumor types and drug modalities (small molecules, biologics, peptides, glues)
- Companion diagnostic experience across countries and through regulatory approval
- Ability to conduct analysis across multi-omic datasets independently and in collaboration with biometrics
- Experience utilizing AI to enhance translational work
Culture and valuesWe are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.
ThoughtfulThoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.
BraveBrave at Iso is about fearlessness, but it's also about initiative and integrity. The scale of the challenge demands nothing less.
DeterminedDetermined at Iso is the way we pursue our goal. It's a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won't wait, so neither should we.
TogetherTogether at Iso is about connection, collaboration across fields and catalytic relationships. It's knowing that transformation is a group project, and remembering that what we're doing will have a real impact on real people everywhere.
Creating an extraordinary companyWe believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.
Hybrid workingIt's hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and
would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you're in). If you have additional needs that would prevent you from following this hybrid approach, we'd be happy to talk through these if you're selected for an initial screening call.
