Advisor Chemistry and Chemical Biology

Protomer Technologies is a wholly owned subsidiary of Lilly, a startup within Lilly, that focuses on chemical biology, molecular switches and (oral) peptidic macrocycles platforms. This position is focused on deep technology development in chemical biology, specifically peptides and macrocycles with a particular focus on peptide libraries, and oral macrocyclic peptides. Protomer team engages in disease-relevant biological systems in order to test preclinical and clinical pipeline of innovative medicines. The candidate is expected to help develop strategy, direction and manage scientific group milestones and objectives based on an ambitious long-term strategic plan which the candidate helps to develop. The ideal candidate is a significant contributor and leading a highly integrated, agile, and collaborative team effort and expected to manage the scientific portfolio, the business supporting the portfolio, and mentoring of junior scientists within the insulin engineering group at Protomer. Ideal candidate is expected to have demonstrated success in similar roles with proven track record of leading both scientific rationale, planning and execution leading to success in making medicines. Responsibilities: • Lead projects in insulin engineering, chemical biology or peptide frameworks combining aspect of molecule design and conjugation at the interface of small molecules and peptides. • Initiate and lead new projects, can formulate strategy and execute on the strategy organizing efforts for deep technical development and to accelerate projects internal to the team. • Work collaboratively in the group to achieve a common goal but also provide independent perspective and scientific rationale and contribute to strategy and execution. • Balance science and the business of science by delivering the small and large (peptides) molecule portfolio through responsible planning, execution, and completion of projects. • Work on and lead (both directionally and operationally) molecule engineering efforts from lead identification to lead optimization and contribute along the way to phase 1b and beyond. • Take on dedicated molecular engineering efforts towards targets of high conviction and utilize speed and prioritization to advance synthetic efforts both at Protomer and wider Lilly groups and through collaboration with the rest of LRL. • Learn about and enhance the platform technology efforts at Protomer. • Inspire people to collaborate in inventing great medicines by removing barriers, committing to high quality scientific hypotheses, and accelerating where possible. • Keep safety as a top priority at all times, striving toward a proactive safety culture. • Be an advocate for diversity and inclusion in our recruiting, retaining and developing scientists, with a commitment to coaching and development of scientists. • Be a good team player and work effectively, responsibly and professionally with colleagues at Protomer and across Lilly. Basic Requirements: • PhD in chemistry, synthetic chemistry, chemical biology or peptide chemistry or related field with significant experience in these fields and a proven track record of research success. Additional Preferences: • Familiarity with state of the art in computational and structural efforts for hit identification and lead optimization of peptides. • Great understanding of computational and AI/machine learning techniques used for the development and engineering of peptide medicines. • Demonstrated ability to make decisions in the midst of ambiguity, seeking appropriate level of information from Protomer leadership and enabling workforce to execute against Protomer strategic priorities. • Open, transparent and able to communicate equally well with employees, team members and cross-functional and/or senior leadership. • Promote external environment awareness across workforce and identify and champion Best Practices and their internal dissemination. • Ability to think strategically, actively identifying gaps in competencies or capabilities within the organization and taking initiative to drive continuous improvement across Protomer. • Knowledge of some of the latest developments in peptides, including new chemistries for synthesis and insulin chemistry, diabetes or related fields. • Must be an excellent team player, strong attention to detail, strong problem-solving skills, a high level of learning agility, with the ability to lead within a globally matrixed organization and across functions. Additional Information: • Some domestic and international travel is anticipated and expected. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $141,000 - $231,000 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.