Ph.D. in analytical chemistry, (bio)chemistry, or related field with 7+ years of research experience, including 3+ years in metabolomics/lipidomics or 1 year postdoctoral experience.
Familiarity with high-resolution mass spectrometers (e.g., Orbitraps).
Experience with liquid chromatography, including standard analytical flow.
Strong collaborative skills with a customer service mindset.
Recent bench work experience is essential.
Ability to prepare comprehensive research reports.
Effective verbal and written communication skills.
Responsibilities
Lead multiple projects in collaboration with researchers.
Perform weekly cleaning, calibration, and data quality checks on LCMS instrumentation.
Prepare samples for metabolomics and lipidomics experiments.
Optimize extraction protocols for various samples.
Conduct LC/MS/MS experiments for both targeted and untargeted analyses.
Analyze data using software like TraceFinder and Compound Discoverer.
Consult with researchers on experimental design and data interpretation.
Benefits
Opportunity to work in a state-of-the-art laboratory environment.
Engagement in collaborative research with diverse projects.
Participation in grant writing and manuscript preparation.
Chance to present findings at group meetings and scientific conferences.
Training and supervision of junior laboratory personnel.
Involvement in developing new methods and workflows in metabolomics/lipidomics.
Full Job Description
Overview
The UMass Chan Metabolomics Core Facility is seeking an enthusiastic and motivated individual to support metabolism-based research projects in a variety of experimental models using high-resolution, accurate-mass, liquid-chromatography mass-spectrometry. Under the direction of the Core Director, you will provide professional operational support to our metabolomics and lipidomics platform by performing bench level experiments. You will collaborate with researchers in developing and applying LC/MS-based metabolomics/ lipidomics to advance their research projects. You will use discretion in prioritizing and organizing workflows. You will be expected to work independently and as part of a team to ensure high-quality data acquisition in a state-of-the-art laboratory.
Responsibilities
Responsibilities
Serve as project lead on multiple projects with different collaborators
Assist with weekly cleaning and calibration of LCMS instrumentation and data quality checks
Prepare samples for metabolomics/ lipidomics experiments
Optimize extraction protocols
Assist researchers with metabolite extractions
Perform LC/MS/MS experiments for targeted and untargeted metabolomics and lipidomics
Perform data analysis using software such as TraceFinder, Compound Discoverer and LipidSearch
Consult with researchers on experimental design and data interpretation
Produce reports and share them with collaborators
Participate in grant writing and manuscript preparation
Present data at group meetings, may attend scientific conferences
Operate, maintain, and troubleshoot a variety of mass spectrometers
Develop new metabolomics/ lipidomics methods and workflows when needed
Assist with general laboratory tasks as needed
Maintain detailed records and adhere to SOPs
Supervise and train new laboratory personnel and junior members of the laboratory
Serve as EHS contact and monitor and enforce laboratory safety standards
Performs other duties as assigned.
Qualifications
REQUIRED QUALIFICATIONS:
Ph.D. in analytical chemistry, (bio)chemistry, or a related field, with at least 7 years of research experience, including a minimum of 3 years of experience in metabolomics and/or lipidomics or at least 1 year of postdoctoral research experience
Familiarity with high-resolution mass spectrometers (e.g. Orbitraps)
Experience with liquid-chromatography (including standard analytical flow)
Willingness to work in a collaborative environment with an outfacing customer service acumen
Recent bench work experience required
Ability to prepare research reports
Good verbal and written communication skills
Demonstrated ability to understanding scientific, experimental and or research theory
PREFERRED QUALIFICATIONS:
Experience with lipidomics (in addition to metabolomics) strongly preferred
Experience with gas-chromatography/ NMR/ other methods of analyzing metabolism
An understanding of the use of stable isotopes in tracing experiments
A broad knowledge of open-source, high-resolution, accurate-mass data analysis software
Experience in advanced data processing and analysis encouraged (use of Matlab, R, Python etc)
Familiarity with statistical methods used in larger cohort studies
Willingness to explore and adopt AI into the metabolomics workflow
Additional Information
Environmental Working Conditions:
Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.
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About University of Massachusetts Medical School
The University of Massachusetts Medical School (UMMS) is a world-class research institution with a uniquely collaborative spirit, that consistently produces noteworthy advances in clinical and basic research. The school is located in Worcester, Massachusetts and is part of the University of Massachusetts system. UMMS is dedicated to advancing the health and well-being of the people of the commonwealth and the world through pioneering advances in education, research, and health care delivery. The school is home to three Nobel laureates, 25 research centers, and a faculty of more than 1,200 physicians, scientists, and health care professionals.
