Why this role matters.Our gene editing programs for neurodegenerative diseases can only advance if in vivo studies show that an editor works in a living animal. This role carries those studies from dosing through tissue collection to the molecular readout. The data you generate feeds the preclinical and IND-enabling work that decides whether a program moves forward.
This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4-5 days per week.
What you'll own.- Run in vivo pharmacology studies in rodents, including dosing, monitoring, clinical observations, blood collection, tissue harvest, and necropsy.
- Set up and schedule studies, and coordinate between the laboratory and the animal facility.
- Process tissues and biological samples, and isolate DNA, RNA, and protein for molecular, biochemical, and pharmacodynamic analysis.
- Run assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope.
- Analyze, interpret, and graph study and assay data in GraphPad Prism and other analysis tools.
- Present findings, study progress, and data summaries to project teams and cross-functional collaborators.
- Keep study records, sample inventories, and protocols accurate and current.
What you've done. - Bachelor's degree in pharmacology, biology, neuroscience, molecular biology, or a related field with 3+ years of industry experience, or a master's degree with 1+ year.
- Has run in vivo rodent studies hands-on, including dosing, monitoring, blood collection, tissue harvest, and necropsy.
- Has dosed rodents by intravenous, retro-orbital, or comparable routes.
- Has processed animal tissues and biological samples for molecular, biochemical, or pharmacodynamic endpoints.
- Has run molecular and biochemical assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope; flow cytometry experience preferred.
- Has managed samples and timelines across more than one study at a time.
- Has supported IND-enabling studies (preferred).
What you'll get.The anticipated base salary range for this role is $85,000-$95,000. Actual pay depends on relevant experience, skills, education, internal equity, and other job-related factors.
Every employee is eligible for a bonus and new hire equity. We pay about 90% of medical, dental, and vision premiums and fund the full deductible on our HSA plan. You'll also get 12 weeks of parental leave at full pay, paid parking or transit, a 401(k) match, and discretionary time off.
