BS with 3+ years or MS with 1+ years in cell biology, molecular biology, or related field
Experience in high-throughput cell-based screens, preferably with primary T cells, hepatocytes, or cancer cell lines
Hands-on experience with gene editing technologies like CRISPR and base editors
Familiarity with laboratory automation and flow cytometry
Experience with nucleic acid QC methods such as TapeStation and qPCR
Proven ability to generate precise, reproducible data and conduct quantitative analysis
Strong communication skills for presenting technical information to diverse audiences
Exceptional organizational skills for managing complex datasets and projects
Responsibilities
Execute cell-based assays and high-throughput screening workflows independently and collaboratively
Develop and conduct rigorous arrayed and pooled HT screening campaigns
Troubleshoot experiments and analyze data to derive actionable insights
Maintain detailed lab notebooks and communicate findings to the scientific team
Collaborate cross-functionally to advance optimized candidates into development
Benefits
Collaborative and innovative work environment
Opportunity to work on cutting-edge genome editing technologies
Engagement in cross-functional projects
Support for professional development and growth
Access to advanced laboratory automation tools
Full Job Description
About the Role:
Stylus Medicine is seeking a Senior Research Associate to join our Genome Sciences & Engineering team. In this role, the Senior Research Associate will drive the execution of cell-based assays and high-throughput screening workflows to advance the company's LSR-based genome editing platforms. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing.
Key Responsibilities & Accountabilities:
Execute cell-based assays and high-throughput (HT) screening workflows that advance platform and program objectives, working both independently and as part of a cross-functional team
Develop and execute arrayed and pooled HT screening campaigns with rigor and reproducibility
Troubleshoot experiments, analyze data, and translate results into actionable scientific insights
Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team
Partner cross-functionally to advance optimized candidates into translational and preclinical development
Qualifications & Skills:
BS with 3+ years or MS with 1+ years relevant experience in cell biology, molecular biology, or a related field
Experience conducting high-throughput cell-based screens; proficiency with primary T cells, hepatocytes, and/or cancer cell lines, working with LNPs preferred
Hands-on experience with gene editing technologies (e.g. CRISPR nucleases, recombinases, base editors, or transcriptional effectors)
Familiarity with laboratory automation platforms for cell-based screening workflows, flow cytometry
Experience with nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
Track record of independently generating precise, reproducible data and performing rigorous quantitative analysis
Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences
Exceptional organizational skills and comfort managing complex datasets and overlapping projects
Strategic thinker who effectively plans and prioritizes to maximize scientific impact
Collaborative mindset with a team-first attitude
Creative problem-solver who thrives amid scientific uncertainty
