Senior Machine Learning Engineer

Tahoe Therapeutics

• $150K — $180K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • Degree in Computer Science, Mathematics, or equivalent experience.
  • Strong engineering skills for data processing and training pipelines.
  • Experience in building, testing, and deploying neural network architectures like Transformers.
  • Familiarity with PyTorch, Tensorflow, Keras, JAX, and hardware-optimized distributed training.

Responsibilities

  • Adopt state-of-the-art machine learning techniques for virtual cell models.
  • Collaborate with ML scientists to develop optimized models like Tahoe-x1.

Benefits

  • Unlimited Paid Time Off (PTO).
  • Monthly lunch budget.
  • One-time office setup budget.
  • Comprehensive medical, vision, and dental plans for employees and dependents.
Full Job Description
Your role

With Tahoe-100M, we solved one of the fundamental bottlenecks in building a virtual model of the cell: generating massive, perturbation-rich, single-cell datasets that capture real biological causality. With Tahoe-x1, we removed the second bottleneck: creating a modern platform for rapid iteration on model architectures and designs in a cost-efficient manner and at scale. At Tahoe, we embody a simple philosophy: build in the open, shoot for the moon, and we're looking for people who want to push the frontier of what's possible.

As a Senior Machine Learning Engineer, you will play a leading role in designing the next generation of foundation models of gene regulatory networks powered by Tahoe's large scale single-cell datasets such as Tahoe-100M and beyond. This role is well-suited for someone with a strong background in machine learning and statistics, and an interest in applying cutting-edge breakthroughs in ML to meaningful problems in drug discovery. We are looking for non-incremental thinkers with the skills to help build models that can make a real impact on drug discovery.

Qualifications - Required

  • Solid Engineering and Computer Science fundamentals, ideally with a degree in CS, Math, or equivalent experience.
  • Exceptional engineering skills to iterate quickly on data processing and training pipelines
  • Experience in building, testing, training, and deploying modern neural network architectures such as Transformers.
  • Experience with frameworks like PyTorch, Tensorflow, Keras, JAX and the ability to write hardware optimized code for distributed training


Qualifications - Desirable

  • Experience with distributed deep learning using frameworks such as HF Accelerate, Deepspeed, Composer, TorchTitan, Megatron etc.
  • Experience with training large neural networks on multiple compute nodes.


Key Responsibilities

  • Stay at the forefront of ML and computational biology research and rapidly adopt state-of-the-art techniques to train AI virtual cell models on our massive single cell datasets.
  • Work together with ML Scientists to develop the next generation of compute optimized models like Tahoe-x1.


Benefits

  • Unlimited Paid Time Off (PTO).
  • Monthly Lunch budget
  • One-time Office set up budget
  • US Employees: HMO Kaiser Platinum and PPO Anthem Gold medical as well as vision and dental plans for both the employee and dependents.


This position requires on-site presence at our South San Francisco office a minimum of three days per week.

We welcome applicants who require visa sponsorship and provide work authorization support for qualified candidates.

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