Senior Director, Translational MedicineDepartment: Research & Development
Reports To: President, Research & Development
Location: Boston, MA (Hybrid)
The RolecAMPfield is seeking a Senior Director of Translational Medicine to build and lead the translational strategy connecting prifemilast's mechanism of action (PDE4B-selective inhibition and cAMP-mediated modulation of mucosal inflammation) to clinical outcomes in IBD This leader will design and oversee the biomarker, endoscopic, histologic, and pharmacodynamic strategy across our clinical portfolio, and will play a central role in informing dose selection, patient stratification, and mechanistic differentiation versus other IBD therapies. This is a senior, highly visible role reporting into R&D leadership with regular exposure to the executive team and board.
Key Responsibilities- Define and lead cAMPfield's translational medicine strategy across the prifemilast clinical program, from Phase 2 through registration-enabling studies.
- Design biomarker, pharmacodynamic, endoscopic, and histopathology sample strategies that link target engagement and mechanism of action to clinical response in IBD.
- Partner with Clinical Development, Clinical Pharmacology, and Biostatistics to integrate translational endpoints into protocol design and data analysis plans.
- Identify and validate biomarkers of disease activity, mucosal healing, and treatment response; explore predictive biomarkers to support patient stratification.
- Evaluate and manage relationships with central reading, histopathology, bioanalytical, and companion diagnostic vendors and academic collaborators.
- Translate emerging preclinical and clinical biomarker data into actionable recommendations for program strategy, including dose selection and lifecycle opportunities.
- Represent translational medicine in regulatory interactions and health authority briefing documents.
- Contribute to scientific publications, congress presentations, and investor/board materials describing prifemilast's mechanism and differentiation.
- Build and mentor a translational medicine function as the organization grows.
Qualifications- PhD, MD, or MD/PhD in immunology, pharmacology, gastroenterology, or a related field.
- 12+ years of translational medicine or translational research experience in biotech or pharma, including direct experience in immune-mediated inflammatory disease (IBD experience strongly preferred).
- Demonstrated track record of designing and executing biomarker strategies that influenced clinical development decisions (e.g., dose selection, go/no-go decisions, patient stratification).
- Deep understanding of GI mucosal immunology and/or PDE4/cAMP signaling biology is a strong plus.
- Experience working with endoscopic and histologic endpoints in IBD trials preferred.
- Strong publication record and experience representing translational science externally to KOLs, regulators, and scientific conferences.
- Demonstrated leadership experience building or managing a translational medicine or biomarker function.
- Excellent cross-functional collaboration skills and comfort operating in a lean, fast-moving biotech environment.
What We Offer- A rare opportunity to shape the clinical and scientific strategy of a well-funded, Series A biotech advancing a differentiated oral therapy in a large, underserved market.
- A collaborative, science-first culture built by leaders who have taken IBD and immunology therapies from early development through approval.
- Direct exposure to the executive team and board, with real influence over pipeline and program decisions.
- Comprehensive health benefits, equity participation, and a flexible hybrid work model across our San Diego and Boston hubs.
How to ApplyTo apply, please submit your resume/CV and a brief note on your interest in cAMPfield's mission to [redacted].
