Position Summary:The Senior Director, Head of Global Supply Chain is accountable for reliable, compliant, and cost-effective clinical and commercial supply of ZYNLONTA® though ADC Therapeutics' strategic external manufacturing network. Reporting to the Vice President, Global Operations and Supply, this leader owns end-to-end supply planning, enterprise S&OP, inventory strategy, and supply chain performance across ADC Therapeutics' external manufacturing network.
ADC Therapeutics operates in a fully external manufacturing model. The Senior Director serves as a senior external-facing leader and key member on multiple Joint Steering Committees with CDMOs and strategic business partnerships. This individual is expected to build trusted relationships with external partners, align their organizations to ADC Therapeutics' business objectives, improve performance, and drive resolution of all supply, capacity, service, and execution issues. The role requires autonomy, judgment, and executive presence to effectively represent ADC Therapeutics.
Internally, the Senior Director leads Executive Sales and Operations Planning (ES&OP), establishes supply metrics for ADCT Production Management Teams, manages a cost-effective inventory strategy, and provides executive-level visibility to supply performance. This is a highly visible leadership position who drives accountability to the supply plan across the entire value chain.
The successful leader will be a strategic, growth-mindset leader who excels in building dynamic staff and teams. They will combine operational rigor with the agility and autonomy required to work directly with CDMO leadership, influence CDMO priorities, secure commitments, challenge performance, and resolve complex supply issues with an unwavering focus on patient supply, quality, and business continuity.
What You'll Do :Clinical and Commercial Supply- Own end-to-end supply planning and execution for ZYNLONTA commercial supply and clinical programs.
- Lead the Tech Ops Management Tier to align ADCT business needs with CDMO supplier performance.
- Serve as a contributing member of Joint Supply Committees with global partners.
- Ensure Tech Ops supply plan ensure uninterrupted supply for Commercial, Clinical and global business partners.
- Lead scenario and recovery planning for demand shifts, production delays, quality events, and supply interruptions.
- Drive cross-functional resolution of constraints and maintain executive visibility to supply continuity and key risks.
Executive S&OP Leadership (ES&OP)- Lead ES&OP, integrating commercial forecasts, clinical demand, CDMO forecasts, inventory, financial implications, and strategic priorities into one operating plan.
- Establish a disciplined monthly cadence for demand review, supply review, reconciliation, and executive decision-making.
- Partner across Commercial, Clinical Development, Finance, Technical Operations, Quality, Regulatory, Procurement, and Business Development to align assumptions, trade-offs, and decisions.
- Translate approved ES&OP decisions into operating plans, inventory targets, external-partner commitments, financial forecasts, and risk-mitigation actions.
- Monitor forecast accuracy, demand variability, plan adherence, and decision effectiveness.
External Supply Network and CDMO Governance- Serve as a core member of the CDMO Joint Steering Committee (JSC), representing the company's end-to-end supply plan.
- Senior operational relationship leader with CDMO executives across manufacturing, testing, packaging, release, logistics, and distribution.
- Translate ADC Therapeutics' business objectives, patient-supply priorities, and operating plans into clear expectations and executable partner commitments.
- Build trusted relationships while maintaining independence to challenge performance, manage conflict, and protect ADC Therapeutics' interests.
- Lead joint operating reviews and executive business reviews, ensuring decisions result in documented commitments, accountable owners, and timely follow-through.
- Establish fit-for-purpose governance with clear decision rights, forums, escalation pathways, performance expectations, and executive engagement.
- Proactively influence CDMO priorities, resource allocation, capacity decisions, production schedules, and recovery plans.
- Lead executive escalation and resolution of material supply or performance issues, including root-cause analysis, recovery plans, and sustainable corrective actions.
- Maintain a network-wide KPI scorecard covering on-time-in-full delivery, schedule adherence, cycle time, testing and release performance, capacity, inventory, responsiveness, and action closure.
- Represent Tech Ops in CDMO contract negotiations, capacity reservations, supplier-risk assessments, business continuity planning, and network-strategy decisions.
Inventory Management Strategy- Own global inventory strategy across raw materials, intermediates, drug substance, drug product, finished goods, and market inventory.
- Define inventory segmentation, safety-stock targets, planning parameters, reorder policies, and escalation thresholds.
- Balance patient service, supply risk, shelf life, obsolescence exposure, and cost.
- Establish an inventory management structure that supports ADTC's objectives and mitigates product expiry risk, excess and obsolete inventory, inventory reconciliation, and product disposition.
- Partner with Finance on inventory assumptions, provisions, write-off risks, and COGS projection.
Compliance, Systems, and Data- Ensure supply chain processes are compliant with applicable GxP, traceability, serialization, DSCSA, and company requirements.
- Maintain inspection-ready processes, records, SOPs, metrics, and decision documentation.
- Sponsor effective implementation of ERP, planning, serialization, reporting, and visualization tools, with clear data ownership and master-data standards.
- Establish dashboards that provide actionable visibility to supply, demand, inventory, partner performance, risk, and financial impact.
Leadership- Lead, coach, and develop the global supply chain team, with clear objectives and accountability.
- Be a visible example of ADC Therapeutics iCORE culture (improve, Collaborate, Organize, Risk management, Execute).
- Encourage accountability, embrace issues as learning opportunities, and emphasize the value continuous improvement can bring to our patients, product and business, across the broader Tech Ops organization.
- Influence across the external manufacturing network.
- Ready to be hands-on, as need, in pursuit of establishing "what good looks like." Encourage CDMOs, teams and individuals to leverage a growth-mind set toward continuous improvement journey.
Requirements
Who You Are :- Bachelor's degree in supply chain, engineering, business, operations, life sciences, or a related field required; advanced degree preferred.
- 12+ years of progressive supply chain experience in biotechnology or pharmaceuticals, including accountability for global clinical and commercial supply.
- Expert in managing governance processes of CDMOs, testing laboratories, packaging providers, logistics partners, and other external supply organizations.
- Extensive experience working directly with CDMO site leadership teams, business leaders, supply chain executives, and Quality leadership.
- Proven ability to translate company strategy into partner commitments, influence CDMO performance, secure capacity, and schedule priority, and lead executive escalations with recovery plans.
- Strong experience leading ES&OP or integrated business planning, inventory strategy, capacity planning, and supply risk management.
- Demonstrated effective leadership in both large and small biopharmaceutical companies, combining large-company rigor with small-company agility, autonomy, and hands-on execution.
- Strong executive presence, negotiation skills, financial acumen, and ability to balance collaborative CDMO relationships with constructive challenge and accountability.
- Prior experience implementing ERP systems in a biopharmaceutical or manufacturing environment.
- Working knowledge of GxP, traceability, serialization, DSCSA, change control, deviation management, and inspection readiness.
- Ability to travel domestically and internationally based on business needs (up to 20%).
What We Offer :- Competitive biotech base salary, annual target bonus (eligibility based on company performance) or quarterly IC (field sales roles) and new hire stock options - so you share in the value you help create
- Medical, Dental and Vision benefits which start on the 1st day of employment
- 401(k) with company match
- Paid time off and company holidays including a company wide shut down at the end of the year
- Paid Parental Leave, Life and Disability Insurance, Tax advantaged health savings and spending accounts
- A hands-on, collaborative culture with other passionate biotech professionals
- Mission-driven work that puts patients first
