Senior Bioinformaticist - Gastroenterology/Hepatology

Location
SAINT LOUIS, MO 63110Scheduled Hours
40

Position Summary
Assists in developing and conducting research projects, including experiment design, data analysis, and documentation of experiment results.

Our long-term goal is to understand the complex interactions between HBV and its host that drive viral persistence and to use these insights to identify new strategies toward a functional cure for chronic hepatitis B, which remains a major global health challenge and an important cause of liver related morbidity and mortality.
Our laboratory has a strong history of developing innovative human models of viral infection. We were among the first groups to establish hepatitis B and hepatitis C virus infection models using stem cell-derived hepatocytes, and we have continued to combine these systems with primary human hepatocytes, CRISPR/Cas9 gene editing, and genetically distinct HBV clones to dissect the host and viral factors that determine infection and persistence. Recent work from the laboratory, published in Cell, identified a nucleosome-level molecular switch that primes and influences HBV infection (10.1016/j.cell.2025.01.033.

Job Description

Primary Duties & Responsibilities:

• Independently develop a wide variety of computer programs to meet the needs of data collection, quality control, analysis and report generation.
• Lead and manage research projects and work together with junior members to complete data processing and analysis following specific timelines.
• Lead complex data analysis and writes interpretative reports for Principal investigators.
• Lead and collaborate within cross-functional teams.
• Lead analytical support for internal projects and external collaborations.
• Supervise database structure: includes updating, validating, curating and harmonizing longitudinal, cross-sectional data from different sources.
• Provide a centralized, confidential and secure access to phenotypic data to Principal investigators.
• Lead the response to data queries from Principal Investigators and external collaborators.
• Create reports and prepare highly technical presentations.
• Write manuscripts and communications for conference presentations.
• Present data in meetings and conferences.
• Other duties as assigned.

Working Conditions:
Job Location/Working Conditions

• Normal office environment

Physical Effort

• Typically sitting at a desk or table

Equipment

• Office equipment

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:
Bachelor's degree or combination of education and/or experience may substitute for minimum education.

Certifications/Professional Licenses:
No specific certification/professional license is required for this position.

Work Experience:
Relevant Experience (12 Years)

Skills:
Not Applicable

Driver's License:
A driver's license is not required for this position.

More About This Job

Preferred Qualifications

• Strong background in PLINK, QC, IBD, PCA.
• Knowledge of association analyses, PRSice, MAGENTA, Mendelian Randomization, MANTRA, Coloc, QTL and Unix/Linux.

Preferred Qualifications

Education:
Master's degree, Ph.D. - Doctor of Philosophy

Certifications/Professional Licenses:
No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience:
No additional work experience unless stated elsewhere in the job posting.

Skills:
Association Analysis, Bioinformatics, Biostatistics, Computational Biology, Computer Science, Docker (Software), Java (Programming Language), Linux, Linux Bash, Microsoft Excel, Perl Programming, PLINK (Software), Principal Component Analysis (PCA), Python (Programming Language), Quality Control Tools, R Programming, Scientific Programming Language, Statistical Analysis Software (SAS), Statistical Genetics, Structured Query Language (SQL), Unix Operating Systems

Grade
R13

Salary Range
$72,900.00 - $132,200.00 / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

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