California, US residents click here.
The job details are as follows:The successful candidate will drive process optimization through experimental design, data analysis, and technology transfer activities, while ensuring scientific rigor, documentation accuracy, and alignment with regulatory and quality requirements.
This role will play a critical part in advancing recellularization platforms from research and development through process characterization and clinical manufacturing readiness. Lead, develop and perform hands-on design, optimization, and execution of lung scaffold recellularization experiments using iPSC-derived cells, and drive continuous improvement of recellularization methods.
- Prepare organs, tissues, and cells for experimentation using appropriate surgical handling techniques, dissection, cannulation, and suturing
- Develop new techniques, laboratory procedures and protocols as indicated to support lung scaffold recellularization and characterization efforts using iPSC derived cells
- Develop strategies to seed multiple iPSC derived cell types into lung scaffolds
- Evaluate the vascular integrity (vascular leak, blood perfusion, etc.) of lung tissues, including native lungs, decellularized lung scaffolds, and tissue engineered lung constructs
- Apply and adapt existing assays to evaluate cell phenotype and function on scaffolds recellularized with iPSC-derived cells
- Routinely perform molecular and cell biology assays to evaluate cell distribution and cell phenotype in recellularized scaffolds
- Analyze and integrate data from multiple components of the recell process to draw conclusions for improvements to strategy development
- Coordinate shipment of samples for outsourced testing
- Maintain data integrity and a well-run laboratory by following Good Documentation Practices (GDP) and GLP-like standards, including accurate, contemporaneous recording of all data in the in-house system(s) and keeping the lab clean, organized, and safe
- Record and manage use of materials and reagents needed to carry out experiments
- Follow proper procedures regarding laboratory safety, use of personal protective equipment, and handling of biohazard materials, including human or animal cells and tissues
- Supervise/lead/mentor laboratory personnel and team members as required for specific tasks
- Collaborate closely with the iPSC production and differentiation team to align cell supply, quality, and timelines with recellularization needs, and with the process development team to adapt and optimize existing recellularization protocols for iPSC-derived cells
- Manage day-to-day laboratory operations, including housekeeping, inventory and ordering of materials and reagents, and equipment upkeep, so the lab stays clean, organized, safe, and fully supplied
- Direct and manage direct reports to include responsibilities for training, goal setting & achievement, performance evaluations/management, coaching, mentoring, career development and provide support for recruitment process (as needed)
- Perform other duties as assigned
Minimum Requirements
- Doctor of Philosophy (PhD) in life science or biomedical science
- 2+ years of relevant pharmaceutical or academic research experience
- Prior experience required in Regenerative Medicine (e.g. tissue engineering, decellularization, biomaterials)
- Exceptional ability to lead, mentor and motivate team members
- Strong written and verbal scientific communication/presentation skills
- Strong team work/demonstrated ability to work well with others in a fast-paced, highly interactive environment
- Demonstrated ability to organize and present data
- High degree of self-motivation, with ability to initiate and manage day to day tasks effectively
- Experience with laboratory instrumentation and data software
Preferred Qualifications
- Exposure to lung biology, lung physiology, pulmonary medicine and/or respiratory therapy
Location
This role is based full time in our Silver Spring, MD location.
The salary range for this role is $111,000- $147,000 and reflects our good-faith estimate of the compensation for this role at the time of posting. An employee's position within the salary range will be based on factors such as education, qualifications, experience, skills, geographic location, and business needs, as well as other factors permitted by law at the time of posting. This range may be modified in the future based on company and market factors.
This role is located full time in our Silver Spring, MD office.
Eligible employees may participate in the Company's comprehensive benefits suite of programs, including medical / dental / vision / prescription coverage, employee wellness resources, savings plans (401k and ESPP), paid time off & paid parental leave benefits, disability benefits, and more. For additional information on Company benefits, please visit https://www.unither.com/careers/benefits-and-amenities
