About The RoleWe are seeking passionate and creative individuals who want to contribute to Septerna's mission to utilize innovative drug discovery technologies for GPCR targets. The ideal candidate will have hands-on experience with one or more of the following cellular or biochemical assay systems: NanoBRET, NanoBiT, BRET, TR-FRET/HTRF, Fluorescence Polarization, AlphaLISA/AlphaScreen, or related luminescence- and fluorescence-based assay platforms applied to GPCR or other membrane-proteins systems.
This is full time 12 month contract. The chosen candidate will be working to advance Septerna's Native Complex™ platform by developing quantitative in vitro protein-protein interaction (PPI) assays to purified GPCR proteins, cellular membrane preparations, or whole cells overexpressing the GPCR. This position offers the unique opportunity to join an innovative well-funded biotechnology company and to contribute to its long-term success.
The position is based in South San Francisco, CA. Title and compensation commensurate with experience.
Responsibilities - Perform as a hands-on assay development scientist working within drug discovery project teams to develop and prosecute novel plate-based displacement binding assays.
- Work collaboratively with Discovery Biology colleagues and our drug discovery project teams to prioritize and advance our science.
- Laboratory notebooking, data analysis and documentation.
Qualifications- BS with 10+ years of hands-on relevant in vitro pharmacology experience in a biotechnology or pharmaceutical setting, or a PhD in pharmacology, biochemistry, biophysics or related discipline.
- Experience with developing plate-based quantitative protein-protein interaction (PPI) assays as applied to GPCRs or other membrane-protein systems.
- Deep familiarity with state-of-the-art assay methodologies capable of measuring binding interactions and experience applying towards development of robust, well-controlled high throughput assays.
- Experience with complex data analysis and curve fitting using GraphPad Prism.
- Experience with cell culture, cell engineering and fusion construct design, is a plus.
- Experience with orthogonal binding and biophysical methods, including SPR, co-elution, or pull-down assays, is a plus.
- Demonstrated experience working collaboratively in a team-oriented environment
- Clear and effective verbal and written communication skills
The anticipated salary range for candidates who will work in South San Francisco, CA is $57/hr - $70/hr. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, relevant education or training.
