The RoleArda is seeking an experienced, self-driven scientist to lead in vitro pharmacology projects focused on developing the next-generation of immune-targeting therapies. This individual will play a pivotal role in developing and executing in vitro / ex vivo immunological assays to assess the efficacy of our therapeutic assets, with a particular emphasis on multispecific immune cell engagers. The ideal candidate will possess a strong background in cellular pharmacology, assay development, and large molecule drug screening within the biotech of pharma space. Candidates with previous experience in developing co-culture ADCC, TDCC, cell binding, signal blockings assays and experience working with primary immune cell types including t cells, b cells, nk cells, mast cells, macrophages, and whole blood culture will be prioritized. The ideal candidates will have a proven track record of assay development, large molecule screening, and independently leading projects while functioning as a core team representative. Title will be commensurate with experience.
This position offers a unique opportunity to influence the trajectory of our therapeutic programs and contribute to the advancement of innovative treatments. In addition to a competitive salary, equity, and comprehensive benefits, we provide a flexible time-off policy to support work-life balance. You'll be part of an inclusive, world-class team committed to scientific excellence and innovation.
Responsibilities- Develop, optimize, and perform cell based in vitro / ex vivo cell pharmacology assays to evaluate the function of therapeutic candidates, with a focus on multispecific immune cell engager antibodies.
- Characterize benchmarks and novel engagers across numerous assays for triaging and candidate selection.
- Coordinate efforts with protein science, in vitro, in vivo and ex vivo pharmacology, teams to drive programs from discovery through IND submission or partnering.
Qualifications- Either a PhD in Pharmacology, Immunology, or a related biological science, with a minimum of 2 years of industry; or a master's degree and 6+ years of relevant industry experience.
- Demonstrated expertise in immunology and inflammatory disease space with a focus on developing medium to high throughout in vitro /ex vivo model systems.
- Strong background in immunology and/or inflammation research with experience in primary immune cell isolation, characterization, culture and differentiation.
- Proven track record of contributing to multiple projects and documenting work using electronic notebooks (benchling).
- Excellent communication and collaboration skills, with the ability to work effectively in cross-functional teams.
- Hands-on approach with a desire to independently drive experimental design and execution.
