The PositionArrowhead is seeking a highly motivated Scientist III to join our Discovery Chemistry team at our San Diego site, with a primary focus on ligand and linker synthesis. In this role, you will apply your expertise in organic synthesis to support the development and optimization of siRNA-based therapeutics. This laboratory-based position is ideal for a scientist who enjoys solving challenging synthetic problems, developing reliable methods, and delivering high-quality compounds for biological evaluation.
This role is onsite 5 days a week in San Diego.
Responsibilities
- Design, execute, and troubleshoot organic synthesis workflows.
- Purify and characterize compounds, including ligands and linkers, using chromatography, NMR spectroscopy, and mass spectrometry.
- Coordinate internal and external compound production to support project timelines.
- Monitor scientific literature and apply emerging findings to propose innovative, testable chemical approaches.
- Maintain accurate and thorough records in an electronic laboratory notebook.
- Follow safe laboratory practices.
Requirements- PhD in organic chemistry or medicinal chemistry
- 0-5 years of post-PhD research experience in organic synthesis.
- Proficiency in analytical techniques, particularly NMR spectroscopy, HPLC, and LC-MS.
- Demonstrated ability to independently develop synthetic strategies, solve complex chemistry problems, and guide compound design decisions.
Preferred- Experience with siRNA or antisense oligonucleotides.
- Experience in medicinal chemistry.
- Experience in conjugation chemistry, such as antibody-drug conjugate (ADC).
California pay range
$115,000-$130,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
