Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or related field with 5+ years of biopharma experience, or a Master's degree with 2+ years of experience.
Minimum of 2 years of hands-on laboratory experience in LNP formulation and nucleic acid encapsulation.
Proficiency in LNP characterization methods such as DLS, Zeta potential, and Ribogreen assays.
High proficiency in MS Excel; experience with statistical software like JMP or Prism preferred.
Strong attention to detail and organizational skills, with effective communication in a fast-paced environment.
Preferred experience in targeted LNP preparation and immune cell delivery.
Responsibilities
Execute and optimize formulation and characterization of lipid nanoparticles (LNPs) for nucleic acid delivery.
Implement Design of Experiment (DoE) based screening to establish optimal LNP compositions.
Collaborate with internal teams to support formulation requests.
Support early-stage formulation development and downstream processing activities.
Maintain detailed records of formulation activities and results.
Analyze and present experimental data to the formulation team.
Contribute to routine lab management tasks, including inventory tracking and supply ordering.
Benefits
Medical Insurance - Four plans available for you and your family.
Dental & Orthodontia Benefits.
Vision Benefits.
Health Savings Account (HSA).
Flexible Spending Accounts for Health and Dependent Care.
Voluntary Life Insurance and Disability Insurance.
Hospital Indemnity Insurance.
401(k) plan with matching options.
Paid Sick Time Leave.
Legal and Identity Protection Plans.
Pre-tax Commuter Benefit.
529 College Saver Plan.
Full Job Description
Title: Scientist II - LNP Formulation Description: Onsite: San Diego, CA. No relocations.
Position Summary We are seeking a motivated and detail-oriented Scientist 1 to join our Formulation team. In this hands-on laboratory role, you will work closely with senior scientists to execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery. The successful candidate will be a collaborative team player with strong technical and data analysis skills who is ready to contribute to our non-viral delivery platform.
Responsibilities: • Execute and optimize the formulation and characterization of lipid nanoparticles (LNPs) or targeted lipid nanoparticle (tLNPs) encapsulating nucleic acids for in vitro and in vivo studies under the minor guidance of senior formulation scientists. • Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters. • Collaborate cross-functionally with internal teams to support and fulfill formulation requests. • Support early-stage formulation development and downstream processing activities when needed, including cryoprotection, scale-up, and stability studies. • Maintain detailed records documenting formulation activities and results. • Analyze, interpret, and present experimental data to the formulation team. • Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.
Requirements, Knowledge, Skills, and Abilities: • Education: Bachelors degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 5+ years of biopharma industry experience, OR a Masters degree with 2+ years of industry experience. • LNP Expertise: Minimum of 2 years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA). • Analytical Skills: Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays. • Software & Data: High proficiency in MS Excel is required; hands-on experience with statistical and data analysis software (e.g., JMP, Prism) is preferred. • Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast-paced team environment. • Preferred Skills: Prior experience with targeted LNP preparation (mAb, Fab, ScFv, VHH coated LNP) and immune cell delivery is highly desirable.
You will receive the following benefits:
Medical Insurance - Four medical plans to choose from for you and your family
Dental & Orthodontia Benefits
Vision Benefits
Health Savings Account (HSA)
Health and Dependent Care Flexible Spending Accounts
Voluntary Life Insurance, Long-Term & Short-Term Disability Insurance
Hospital Indemnity Insurance
401(k) including match with pre and post-tax options
