Scientist II, DevelopabilityDepartment: Lab Science
Employment Type: Full Time
Location: San Mateo, CA
DescriptionThe Role: BigHat Biosciences is looking for a hands-on, bench-driven scientist to drive antibody developability assessments that advance our Milliner Platform for AI-designed therapeutics. This is a primarily lab-based role where you'll spend the majority of your time at the bench executing and innovating on our developability workflows.
*At BigHat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that
responsibilities and title would adjust as appropriate.
Key Responsibilities- Lead developability R&D projects: design, optimize, and execute high throughput developability assays to expand BigHat's toolkit.
- Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.
- Support late-stage characterization and IND-enabling studies, including formulation screening, stress testing, peptide mapping, and simulated administration studies, to rank and advance lead candidates.
- Serve as the Developability lead within project teams, guiding experimental strategy to address liabilities and hit program milestones.
- Work cross-functionally to automate and train colleagues on new and existing methods, build QC frameworks for monitoring assay performance, and adapt workflows to existing LIMS infrastructure.
- Proactively and independently analyze data, interpret scientific findings, propose next steps, and broadcast findings clearly across the organization.
Skills Knowledge and Expertise- PhD in Biochemistry or relevant discipline with 3+ year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.
- Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS, including method development and optimization.
- Track record of translating complex data into clear results and recommended actions.
- Experience with protein structures and antibody engineering.
- Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.
- Nice-to-haves include prior experience working in a dynamic start-up environment, working as a project lead, and working with automation.
Total RewardsThe salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:- Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
- Dental, and vision coverage through Guardian
- Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
- 401(k) with company match
- DTO, two weeks of company-wide shutdown, and 12 company holidays
- Paid parental leave
