PositionYou will lead the development of innovative analytical workflows that support and accelerate Nurix's DAC platform, applying your expertise in ADC and/or DAC characterization to solve complex scientific challenges. This is an opportunity to shape analytical strategy for a novel therapeutic platform at the forefront of drug discovery and development.
This is a laboratory role requiring assay design, method development, hands-on execution, and scientific communication to project and platform teams. You will design and execute analytical strategies for high-throughput DAC screening, establish quality criteria that drive conjugate advancement decisions, and partner closely with conjugation chemistry, biology, and bioanalytical teams from early screening through candidate selection.
Responsiblities: - Design, execute and own the DAC screening characterization platform including DAR, aggregation, protein quantitation, and define the QC thresholds to advance conjugates for a program
- Present findings to project and platform teams; collaborate with conjugation chemistry, bioanalytical, and cell screening groups to align workflows, coordinate sample flow, and influence conjugate advancement decisions
- Lead and conduct in-depth characterization of antibodies and advanced DACs including positional isomers, glycosylation analysis, peptide mapping, and stability
- Integrate DAR, purity, hydrophobicity, and stability data into unified assessments with QC cutoffs that drive go/no-go decisions; identify structure-quality trends across antibody, linker, and payload variables
Requirements: - PhD with 4+ years of industry experience in biochemistry, analytical chemistry, or a related discipline
- Expertise in ADC/DAC & antibody characterization from method development to data interpretation
- Expertise with LCMS & HPLC methods for antibody and conjugate analysis, including DAR, SEC, peptide mapping, HIC, and other relevant industry leading methods
- Direct experience characterizing ADCs in an industry setting with working knowledge of conjugation chemistry, DAR heterogeneity, and common quality attributes
- Track record of independently designing experiments, developing analytical methods, troubleshooting assay and instrument performance, and managing priorities across multiple concurrent programs
- Ability to synthesize complex analytical datasets into actionable scientific conclusions and influence project decisions through clear communication to cross-functional teams
Preferred Qualifications- Experience with native LCMS, positional isomer analysis, glycan analysis, CE-SDS for expanded conjugate or antibody characterization
- Background in peptide mapping, biophysical binding assays, and thermal stability
- Familiarity with developability assessment, forced degradation, or formulation-support analytics for biologics
- Familiarity & experience with Agilent instrumentation & analytical software (MassHunter, Byos, or equivalent)
Culture & Team Fit:- Ability to work collaboratively across multiple groups within the organization
- Excellent organization and communication with effective presentation skills
- Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment
- Curious mindset with a willingness and flexibility to learn new skills
- High level of creativity and productivity with strong problem-solving skills
Salary Range: 140K - 161K 
