Position Description: Calico is seeking an experienced Process Chemist to join our laboratory-based chemical development team. The ideal candidate brings extensive hands-on experience in process research, route scouting, and scale-up of organic molecules. In this role, you will design, optimize, and execute synthetic processes that enable efficient, safe, and scalable manufacturing of small-molecule intermediates and APIs. This is a lab-focused position requiring strong experimental skills, deep organic chemistry knowledge, and the ability to translate laboratory findings into robust processes.
Key Responsibilities: - Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates
- Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control
- Conduct detailed reaction analysis using, HPLC, GC, LC-MS, and other analytical techniques
- Perform impurity identification and synthesis
- Identify and mitigate process risks related to safety, scalability, and robustness
- Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance
- Prepare clear, data-driven reports and present experimental results to project teams
- Support technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions
- Maintain accurate lab documentation and adhere to all safety and compliance standards
Position Requirements: - PhD in Organic Chemistry or related field with 8+ years of relevant industrial experience in process chemistry
- Strong expertise in synthetic organic chemistry and reaction mechanism fundamentals
- Demonstrated success in developing scalable synthetic processes
- Proficiency with standard analytical instruments and data interpretation
- Excellent problem-solving, organization, and communication skills
- Ability to work independently while contributing effectively to a team environment
- Familiarity with cGMP and ICH guidelines
- Strong attention to detail and a commitment to high-quality experimentation
- Ability to manage multiple projects and shifting priorities
- A proactive, collaborative mindset with enthusiasm for process improvement
- Must be willing to work onsite 5 days a week
The estimated base salary range for this role is $197,000 - $230,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
