PhD in Organic Chemistry or related field with 8+ years of industrial experience.
Strong expertise in synthetic organic chemistry and reaction mechanisms.
Demonstrated success in developing scalable synthetic processes.
Proficient in standard analytical instruments and data interpretation.
Excellent problem-solving and organizational skills.
Ability to work independently and in a collaborative team environment.
Familiarity with cGMP and ICH guidelines.
Responsibilities
Develop and optimize synthetic routes for drug substance candidates.
Perform lab experiments to enhance yields and impurity control.
Conduct detailed reaction analyses using HPLC, GC, LC-MS, and other analytical tools.
Identify and synthesize impurities for process improvement.
Mitigate process risks related to safety and scalability.
Collaborate with teams in analytical chemistry and quality assurance.
Prepare clear, data-driven reports of experimental results.
Benefits
Two annual cash bonuses based on performance.
Opportunity to work in a cutting-edge laboratory environment.
Engagement in cross-functional collaboration.
Potential for impactful work on scalable drug development.
Full Job Description
Position Description:
Calico is seeking an experienced Process Chemist to join our laboratory-based chemical development team. The ideal candidate brings extensive hands-on experience in process research, route scouting, and scale-up of organic molecules. In this role, you will design, optimize, and execute synthetic processes that enable efficient, safe, and scalable manufacturing of small-molecule intermediates and APIs. This is a lab-focused position requiring strong experimental skills, deep organic chemistry knowledge, and the ability to translate laboratory findings into robust processes.
Key Responsibilities:
Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates
Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control
Conduct detailed reaction analysis using, HPLC, GC, LC-MS, and other analytical techniques
Perform impurity identification and synthesis
Identify and mitigate process risks related to safety, scalability, and robustness
Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance
Prepare clear, data-driven reports and present experimental results to project teams
Support technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions
Maintain accurate lab documentation and adhere to all safety and compliance standards
Position Requirements:
PhD in Organic Chemistry or related field with 8+ years of relevant industrial experience in process chemistry
Strong expertise in synthetic organic chemistry and reaction mechanism fundamentals
Demonstrated success in developing scalable synthetic processes
Proficiency with standard analytical instruments and data interpretation
Excellent problem-solving, organization, and communication skills
Ability to work independently while contributing effectively to a team environment
Familiarity with cGMP and ICH guidelines
Strong attention to detail and a commitment to high-quality experimentation
Ability to manage multiple projects and shifting priorities
A proactive, collaborative mindset with enthusiasm for process improvement
Must be willing to work onsite 5 days a week
The estimated base salary range for this role is $197,000 - $230,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
