Full Job Description
Position Overview:
Atrium Therapeutics is seeking an experienced analytical scientist at the Principal Scientist level to build and lead analytical characterization of antibody-oligonucleotide conjugates (AOCs) designed to deliver siRNA payloads selectively to cardiomyocytes. This scientist will develop phase-appropriate analytical methods for AOC drug substance, drug product, and their intermediates (antibody, siRNA duplex, and linker-oligonucleotide). Moreover, the position will generate data that informs conjugation chemistry, process development, stability, and specifications for IND-enabling and early clinical programs. The role is primarily lab-based and will lay a strong foundation for analytical excellence within Chemistry & Technical Development while partnering with Biology, Developmental Sciences, external CDMOs and contract testing laboratories.
Responsibilities:
• Lead efforts to build internal analytical capabilities and laboratory infrastructure.
• Develop, optimize, qualify, and transfer analytical methods for AOCs, oligonucleotide intermediates, and related materials.
• Design and execute forced-degradation and development stability studies; elucidate degradation pathways for both the antibody and oligonucleotide components.
• Serve as analytical lead and provide in-process and release-type analytical testing of oligonucleotides and conjugates in support of discovery, process development, and GLP studies.
• Partner with oligonucleotide and AOC bioconjugation teams to develop analytical methods to characterize and quantify process intermediates and impurities.
• Evaluate and implement new analytical technologies to strengthen oligonucleotide and AOC characterization.
• Maintain rigorous electronic lab notebook records and present data and recommendations to project teams.
• Author and review method SOPs, technical reports, and analytical sections in support of GLP studies and regulatory submissions.
Education and Requirements:
• Ph.D. in analytical chemistry, biochemistry, chemistry or a related field with 8+ years of relevant industry experience; or M.S. with 12+ years; or B.S. with 14+ years.
• Demonstrated analytical leadership on AOC, ADC, or oligonucleotide conjugate programs through IND or later.
• Expert hands-on experience with HPLC/UHPLC (SEC, HIC, IEX, IP-RP) and LC-MS of proteins and/or oligonucleotides, including data processing and deconvolution.
• Experience with capillary electrophoresis (CE-SDS, icIEF) and spectroscopic quantitation.
• Experience with method transfers and impurities characterization through all development phases
• Strong problem-solving skills, attention to detail, and clear written and oral communication in a fast-paced, cross-disciplinary team.
• Demonstrated ability to manage multiple projects independently, prioritize competing deliverables, and meet timelines in a fast-paced, cross-functional environment.
• Familiarity with antibody chemistries and their analytical signatures.
• Experience with SEC-MALS, native MS, peptide mapping, or hybridization-based and ligand-binding assays.
• Publication or patent record in bioconjugate or oligonucleotide analytics.
• Experience with statistical software (e.g., JMP, Design-Expert) for data analysis.
What We Provide:
• The base salary range for this role is $185,000-$205,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
• Atrium offers competitive compensation and benefits which include stock options & RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, LTD, and unlimited of time off including summer & winter breaks.
• A commitment to learning and development which includes a variety of programming internally developed by and for Atrium employees, opportunities for job-specific training offered by industry, and an education reimbursement program.
$185,000 - $205,000 a year
