ML Researcher

Monarch

$160K — $260K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. or equivalent research record in machine learning, statistics, computational science, or a closely related field.
  • Proven ability to define open-ended research questions and create resilient evaluation designs.
  • Proficient in Python and familiar with modern machine-learning frameworks.
  • Experience analyzing noisy, limited, multimodal, or experimental datasets.
  • Skilled in bridging theory, implementation, and scientific interpretation.

Responsibilities

  • Research models using molecular and experimental data to extract valuable insights.
  • Develop methods for active learning and sequential experiment selection.
  • Establish various evaluation frameworks for retrospective and prospective assessments.
  • Analyze which behavioral signals are consistent versus those that may introduce noise.
  • Adapt models based on failures to enhance future training and experimentation.
  • Clearly communicate results and recommendations to help scientists make informed decisions.

Benefits

  • Equity sharing opportunities to enhance overall compensation.
  • Collaborative work environment encouraging innovative research.
  • Focus on groundbreaking experimental methodologies.
  • Opportunity to engage with multidisciplinary teams and diverse datasets.
Full Job Description
Full-time, in-office in Emeryville, California. $160,000-$260,000 annual base salary plus equity.

Develop the learning methods that turn repeated assays into better scientific decisions. The central question is prospective: can a model use prior compound, assay, and behavior data to recommend an experiment that is more informative than the one scientists would otherwise run?

Key Responsibilities
• Research models that combine molecular information, formulation and dose, assay metadata, video-derived behavior, and laboratory context
• Develop active-learning and sequential experiment-selection methods that balance predicted efficacy, uncertainty, novelty, and information value
• Define retrospective and prospective evaluations, including holdouts by chemical scaffold, laboratory, colony, and time
• Investigate which behavioral signals generalize across experiments and which reflect confounding, measurement noise, or laboratory-specific effects
• Translate model failures into new labels, assay variants, controls, or experiments that improve the next training cycle
• Communicate results with enough precision that experimental scientists can understand why a recommendation should or should not be trusted

Qualifications
• Ph.D. or equivalent research record in machine learning, statistics, computational science, or a closely related field
• Demonstrated ability to formulate open-ended research questions, build strong baselines, and design evaluations that survive distribution shift
• Strong software skills in Python and a modern machine-learning framework
• Experience working with noisy, limited, multimodal, or experimentally generated datasets
• Ability to move between theory, implementation, and scientific interpretation

Desired Attributes
• Experience with active learning, Bayesian optimization, reinforcement learning, causal inference, or scientific foundation models
• Experience in molecular discovery, biology, animal behavior, robotics, or another domain where models learn from physical experiments
• Track record of prospective validation rather than benchmark-only research
• Strong research taste and comfort abandoning an attractive idea when the evidence does not support it

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