Xeris Pharmaceuticals

Manager, Cybersecurity Operations

Xeris Pharmaceuticals • $120K — $165K *
Chicago, IL 60629In-Person
Information Technology
5 - 7 years of experience
Today
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Job Overview by Ladders

Qualifications

  • Bachelor's degree in computer science, information systems, cybersecurity, or equivalent experience.
  • 5+ years of progressive cybersecurity experience with leadership responsibility.
  • Hands-on experience with IAM, SIEM, and vulnerability management tools in a Microsoft-centric environment.
  • Strong understanding of cybersecurity frameworks (e.g., NIST CSF, ISO 27001, CIS) and their operational application.
  • Proven ability to lead incident response and communicate with both technical and non-technical audiences.

Responsibilities

  • Lead security operations including monitoring, triage, and incident response for various platforms.
  • Coordinate Managed Detection and Response (MDR) and SOC partners to ensure effective investigations.
  • Manage and coach the security operations team and collaborate with other departments to embed security.
  • Establish checks and balances between IT and cybersecurity for independent governance.
  • Develop and improve runbooks and SOPs for security events and operational tasks.
  • Oversee root cause analysis and conduct threat hunting activities across diverse workloads.
  • Drive incident lifecycle management by tracking metrics, trends, and remediation progress.

Benefits

  • Hybrid working environment with a minimum office presence requirement.
  • Potential for evening and weekend work, with occasional overnight travel.
Full Job Description
Job Description:

The Manager, Cybersecurity Operations owns day to day security operations and incident response, with a strong focus on Microsoft Azure, Microsoft 365 (including Defender, Purview, DLP, and IRM), and key SaaS platforms. This role provides both strategic and hands-on leadership for the security operations team and is accountable for the effectiveness and maturity of security operations in support of the company's risk management and compliance programs.

Essential Job Functions
  • Lead the security operations function, including monitoring, triage, and response for alerts across Azure, Microsoft 365, Windows 365, endpoints, identity, email, and core SaaS applications.
  • Direct and coordinate Managed Detection and Response (MDR) and SOC partners, ensuring clear runbooks, effective SLAs, and high quality investigations and escalations.
  • Manage and coach the security operations team, partnering with Infrastructure, Applications, Legal, Compliance, and business leaders to embed security into day to day processes.
  • Establish a healthy check and balance between IT and cybersecurity so IT focuses on delivery and operations while cybersecurity independently governs, monitors, and enforces controls across the environment.
  • Develop, maintain, and continuously improve runbooks and standard operating procedures for common security events and operational tasks.
  • Oversee root cause analysis, basic forensics, and threat hunting activities across identity, email, endpoint, and cloud workloads.
  • Drive incident lifecycle management: tracking metrics, trends, remediation progress, and lessons learned for technology and business leadership.
  • Support protection of "crown jewel" assets through data classification, conditional access, and policy enforcement across Microsoft 365 and key business systems.
  • Partner in governance activities, including GRC platform administration, NIST based control assessments, InfoSec steering committee inputs, and security improvement tracking.
  • Perform vendor cybersecurity due diligence (e.g., security questionnaires, DDQs, monitoring enrollment) and manage third party risk operations in partnership with Procurement and Legal.
  • Maintain an accurate inventory of security relevant assets (devices, SaaS applications, privileged accounts) to support monitoring, access control, and vulnerability management.
  • Contribute to security awareness efforts, including annual training, Cybersecurity Awareness Month activities, and targeted campaigns.
  • Partner with the Director of Infrastructure and Security on KPIs, operational risk metrics, and budget planning for tools, services, and managed partners.
  • Identify and recommend opportunities to automate and streamline security operations and system administration.


Skills and Qualifications
  • Bachelor's degree in computer science, information systems, cybersecurity, or equivalent experience; 5+ years of progressive cybersecurity experience with demonstrated leadership responsibility.
  • Hands-on experience with IAM, SIEM, and vulnerability management tools, ideally in a Microsoft-centric environment (Azure AD/Entra ID, Microsoft 365, Defender suite).
  • Strong understanding of cybersecurity frameworks and controls (e.g., NIST CSF, ISO 27001, CIS) and their application in day-to-day operations and governance.
  • Proven ability to lead incident response, coordinate cross-functional stakeholders, and communicate clearly with technical and non-technical audiences.
  • Demonstrated skills in team leadership, collaboration, project management, and written and verbal communication; strong attention to detail and adaptability in a fast-changing environment


Working Conditions
  • This is a hybrid position based in Xeris' Chicago office. A minimum of three days per week in the office is required. On-site requirement may change at management's discretion.
  • Position may require periodic evening and weekend work, as necessary to fulfill obligations. Periodic overnight travel.


The anticipated base salary range for this position is $120,000 to $165,000.

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About Xeris Pharmaceuticals

Xeris Pharmaceuticals is a specialty pharmaceutical company that develops and commercializes ready-to-use injectable and infusible drug formulations. The company's proprietary XeriSol and XeriJect formulation technologies allow for the subcutaneous and intramuscular delivery of highly concentrated, non-aqueous, ready-to-use formulations of peptides, proteins, antibodies, and small molecules using commercially available syringes, auto-injectors, multi-dose pens, and infusion pumps. Xeris' lead product, Gvoke HypoPen, is the first ready-to-use glucagon injection for the treatment of severe hypoglycemia in diabetes patients. The company is also developing a pipeline of other ready-to-use injectable and infusible drug formulations for various indications, including epilepsy, hypoglycemia, and post-operative pain management.
Learn more about Xeris Pharmaceuticals
Size
294 employees
Market Cap
$159 million
Industry
Pharmaceuticals & Biotech
Net Income
-$91.1 million
Founded
2005
5 Year Trend
+115.2%
Revenue
$20.4 million
NASDAQ
XERS
* Ladders Estimates

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