Machine Learning Scientist, Pretraining

Profluent

$200K — $330K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • PhD (or equivalent industry experience) in relevant fields such as Machine Learning or Computational Biology.
  • Experience designing, implementing, and evaluating novel large-scale machine learning models in biomolecular contexts.
  • Publications in major ML conferences or journals showcasing expertise in cutting-edge research.
  • Proficiency with deep learning frameworks like Pytorch or Jax.

Responsibilities

  • Design and develop advanced models for protein design.
  • Collaborate with teams to tailor pretraining techniques for biomolecular applications.
  • Build and optimize infrastructure for protein language model pretraining.
  • Curate datasets and create evaluation tasks for generative models.
  • Analyze, interpret, and present computational approaches and results.

Benefits

  • High-growth opportunity with meaningful impact on future protein design.
  • Competitive compensation package with equity participation.
  • 401(k) with strong employer match.
  • Comprehensive health, dental, and vision insurance.
  • Generous PTO policy supporting work-life balance.
  • Professional development opportunities in AI and biology.
Full Job Description
The Role

We're looking for a motivated and creative Machine Learning (ML) Scientist to drive research into pretraining large-scale deep learning models for biomolecular design. This position offers an opportunity to work at the forefront of generative modeling research across language processing, representation learning, and protein engineering. You should be a self-directed researcher who has the ability to rapidly prototype and evaluate new models and algorithms in the biomolecular domain.

As an early employee, you will proactively shape the direction of our machine learning efforts and collaborate across diverse teams of computational and experimental scientists.

Responsibilities
  • Design and develop state-of-the-art autoregressive, diffusion and representation learning models for protein design
  • Collaborate across the machine learning and protein design teams to apply, adapt and improve pretraining techniques from other domains to biomolecular deep learning models
  • Architect, implement, and optimize core infrastructure to support the pretraining of protein language models
  • Curate relevant datasets and design tasks for rigorous evaluation of generative models
  • Implement, analyze, and interpret multiple computational approaches and present results to colleagues in regular update meetings
  • Work within a collaborative, fast-paced, interdisciplinary team across biology and machine learning to help shape the scientific and strategic vision of the company

Qualifications
  • PhD (or equivalent industry experience) in Computer Science, Machine Learning, Natural Language Processing, Applied Math, Computational Biology, Statistics, or a related field
  • Experience with conceiving of, implementing, and evaluating novel machine learning and pretraining large scale LLMs or other models in biomolecular domain
  • Publications at major machine learning conferences (NeurIPS, ICML, ICLR) or scientific journals (Nature, Science, Nature Biotech, Nature Methods, PNAS) or experience pre-training LLMs at frontier AI/ML labs
  • Experience with modern deep learning frameworks such as Pytorch or Jax

Preferences
  • Familiarity with foundational biology of proteins and nucleic acids
  • Experience developing machine learning models for proteins (language models, structure prediction, design)
  • Experience with cloud compute platforms (GCP, AWS, Azure, OCI)
  • Previous experience in data extraction and curation from bioinformatics data sources
  • Familiarity with wet lab experimental assays and associated limitations

What We Offer
  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Hiring Salary Range

$200,000-$330,000 USD

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