The Position:We are seeking a motivated and scientifically rigorous Bioinformatics Scientist II to contribute to the development of next-generation minimal residual disease (MRD) laboratory-developed tests (LDTs). This role will support assay development efforts through bioinformatics analysis, experimental design, data interpretation, and close collaboration with cross-functional teams.
The ideal candidate is an early-career scientist with a strong foundation in genomics, bioinformatics, and next-generation sequencing (NGS). Candidates may be recent Ph.D. graduates or individuals with 1 to 3 years of postdoctoral or industry experience. The successful candidate will be a creative problem solver, critical thinker, and collaborative scientist who enjoys working at the interface of computational biology and laboratory assay development.
Key ResponsibilitiesBioinformatics Analysis & Assay Development- Contribute to the design, development, evaluation, and optimization of NGS-based MRD assays.
- Perform bioinformatics analyses to support assay development, analytical validation, and performance characterization studies.
- Analyze and interpret complex genomic datasets and communicate findings to project teams.
- Develop and maintain reproducible analysis workflows and scripts for assay development activities.
- Support evaluation of assay performance metrics, including sensitivity, specificity, accuracy, reproducibility, and quality control metrics.
- Participate in benchmarking studies to evaluate and compare bioinformatics methods and analytical approaches.
Experimental Design & Scientific Problem Solving- Collaborate with wet-lab scientists to design experiments, analyze results, and drive data-informed decisions.
- Apply critical thinking and scientific reasoning to investigate assay performance, troubleshoot challenges, and identify opportunities for improvement.
- Contribute to the development of novel computational approaches and analytical methods as needed.
- Document analyses, methods, and study results in a clear and reproducible manner.
Cross-Functional Collaboration- Work closely with assay development, molecular biology, software engineering, biostatistics, clinical, and quality teams to support program objectives.
- Participate in design reviews, technical discussions, and project planning activities.
- Help translate biological and technical questions into computational analyses and actionable recommendations.
- Communicate results effectively to both computational and non-computational audiences.
Quality & Documentation- Follow established quality systems and development processes for regulated diagnostic assay development.
- Contribute to study documentation, development reports, validation summaries, and technical records.
- Support preparation of materials for regulatory submissions, audits, and design-control activities as appropriate.
Who You Are:Required Qualifications- D. in Bioinformatics, Computational Biology, Genomics, Biomedical Engineering, Biostatistics, Computer Science, or a related quantitative field.
- Recent Ph.D. graduate and 2+ years of postdoctoral and/or industry experience or M.Sc and 5+ years of experience.
- Strong understanding of molecular biology, genetics, and next-generation sequencing technologies.
- Experience analyzing NGS data and developing computational workflows using Python and/or R.
- Demonstrated ability to independently analyze complex datasets and draw scientifically sound conclusions.
- Strong critical thinking, quantitative reasoning, and problem-solving skills.
- Excellent written and verbal communication skills.
- Ability to work effectively in a highly collaborative, cross-functional environment.
- Demonstrated scientific curiosity, initiative, and attention to detail.
Preferred Qualifications- Experience supporting development of NGS-based research or diagnostic assays.
- Familiarity with cancer genomics, somatic variant analysis, and liquid biopsy applications.
- Experience working with cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) datasets.
- Knowledge of bioinformatics best practices, reproducible research methods, and software version control tools.
- Experience with cloud computing environments (AWS, Google Cloud, or Azure).
- Exposure to regulated product development environments, including CAP/CLIA, FDA, or IVD development processes.
- Experience collaborating closely with both laboratory and computational scientists.
What Success Looks Like- Demonstrates strong scientific judgment and analytical rigor.
- Develops a deep understanding of assay biology, experimental design, and data interpretation.
- Contributes high-quality analyses that inform key development decisions.
- Builds effective partnerships across wet-lab and computational teams.
- Continuously learns new technologies, methods, and scientific domains.
- Grows toward increasing technical ownership and leadership within assay development programs.
#LI-Hybrid, or #LI-Remote
For candidates based in our
San Diego office, the range is
$134,000 - $166,000.For candidates based in our
South San Francisco office, the range is
$152,000 - $170,000.For candidates working
remote (US), the range is
$122,000 - $158,000.The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to years of experience, skillset, geographic location, industry, education, etc. Base pay is one part of the Total Package that is provided to compensate and recognize employees for their work, and this role may be eligible for additional discretionary bonuses/incentives, and restricted stock units.
Pay range
$122,000-$170,000 USD
What We Can Offer YouVeracyte is a growing company that offers significant career opportunities if you are curious, driven, patient-oriented and aspire to help us build a great company. We offer competitive compensation and benefits, and are committed to fostering an inclusive workforce, where diverse backgrounds are represented, engaged, and empowered to drive innovative ideas and decisions. We are thrilled to be recognized as a 2024 Certified™ Great Place to Work® in both the US and Israel - a testament to our dynamic, inclusive, and inspiring workplace where passion meets purpose.
