PhD or equivalent with 6+ years in QSP/T, (m)PBPK, or related fields
Proven success in preclinical and clinical pharmacology
In-depth knowledge of mechanistic modelling and data interpretation
Proficiency in MATLAB/Simbiology, MoBI, GastroPlus/PK-Sim, R, or similar software
Strong communication skills, both written and oral
Independent, results-driven with a proactive approach to improvement
Responsibilities
Execute the MIDD strategy to propel program advancement
Utilize QSP or (m)PBPK modeling for autoimmune and inflammation drugs
Provide mechanistic modeling and simulation support for programs
Research literature for insights into disease states for QSP modeling
Collaborate with cross-functional teams to enhance understanding of disease mechanisms
Maintain expertise in quantitative systems pharmacology
Present QSP results to cross-functional teams
Benefits
Competitive pay and stock options
Comprehensive medical, dental, and vision insurance
100% Paid Parental Leave
Short- and long-term disability coverage
401(k) company match with immediate vesting
Generous vacation and holiday shutdowns
Various health programs including mental and physical wellness initiatives
Full Job Description
Description
Reporting to the VP of Clinical Pharmacology & Pharmacometrics, the Associate Director, Quantitative System Pharmacology (QSP), will contribute to the Model-informed Drug Development (MIDD) strategy and execution across preclinical, translational and clinical stage programs.
This role may be based in our Waltham, MA headquarters, which would be a hybrid role, or it can also be fully remote. Our office-based employees are required to work in the office three (3) days a week. If remote, travel to headquarters for meetings would be required at the discretion of management.
Responsibilities(including, but not limited to):
Understand and execute the "fit-for-purpose" MIDD strategy to accelerate the program advancement
Experience with QSP or (m)PBPK modeling in autoimmune or inflammation for biologicals (ie, monoclonal antibodies, or other modalities), and bring forward combination drug approaches leveraging QSP models to advance clinical trials
Provide (semi)mechanistic modelling & simulation support and expertise to the assigned programs
Survey literature to gain "fit-for-purpose" understanding of preclinical and/or clinical physiological, pathological, and disease state, to enable quantitative system pharmacology modeling and simulation
Work in close collaboration with biologists, discovery chemistry, clinical pharmacologists, pharmacometricians and other functions to improve our understanding of disease mechanisms, modalities, and/or mono-therapy and combination therapy
Maintain quantitative systems pharmacology expertise in the field
Communicate the QSP/(m)PBPK results to across-function program team
Qualifications:
Requires a PhD degree or equivalent with a minimum of 6+ years of combined academic and biotechnology or pharmaceutical experience in QSP/T, (m)PBPK, mathematics, chemical/biomedical engineer, physics, and/or Translational Sciences, including experience with therapeutic antibodies
Demonstrated success contributing preclinical or translational, and clinical pharmacology related aspects across different stages of programs
Prior experience in QSP(T) with in-depth knowledge of mechanistic modelling and data interpretation, as well as track record supporting this experience
Independent hands-n proficiency in MATLAB/Simbiology, MoBI, GastroPlus/PK-Sim, R, or other software
Ability to effectively present ideas, data interpretation, for complex quantitative clinical concepts in both written and oral communication
Highly motivated and results-driven to deliver for corporate goals in a dynamic biotech environment
Demonstrated strong written and verbal communication skills
Proven mindset of proactive continuous improvement
Efficient independent worker with ability to focus and drive for results
Strong attention to detail
Ability to work in a fast-paced environment and to handle multiple tasks
Strong commitment to ethical standards
Proficient with Microsoft Office suite (i.e., Word, PowerPoint, Excel, Outlook, SharePoint, etc.)
The salary range for this position is commensurate with experience
Viridian offers a comprehensive benefits package including:
Competitive pay and stock options for all employees
Medical, dental, and vision insurance
100% Paid Parental Leave
Short- and long-term disability coverage
Life, Travel and AD&D
401(k) Company Match with immediate company vest
Employee Stock Purchase plan
Generous vacation plan and paid company holiday shutdowns
Various fertility, mental, financial, and proactive physical health programs
About Viridian Therapeutics
Viridian Therapeutics is a biotechnology company that develops gene therapies for inherited diseases. The company's lead product candidate, VRDN-001, is a gene therapy for Friedreich's ataxia, a rare genetic disease that causes progressive damage to the nervous system. Viridian Therapeutics was founded in 2018 and is headquartered in Cambridge, Massachusetts.
