Eli Lilly

Advisor - Genomic Sciences, RNA Therapeutics

Eli Lilly$138K — $224K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. in genomics, molecular biology, genetics, or related field with at least 2 years of postdoctoral or industry experience.
  • Proven ability to independently design and execute NGS-based experiments.
  • Experience in cross-functional team collaboration within pharmaceutical or biotech settings.
  • Strong communication skills to translate complex genomic data for non-specialists.
  • Hands-on experience with spatial transcriptomics and/or single-cell genomics.
  • Familiarity with RNA therapeutics and associated pharmacology.
  • Publication record reflecting contributions to genomics or functional genomics.

Responsibilities

  • Design and execute NGS-based genomics experiments for compound profiling and mechanism-of-action characterization.
  • Identify scientific questions and develop strategies to advance portfolio programs.
  • Establish and optimize functional genomics workflows at screening scale.
  • Integrate data from various sources to inform compound progression decisions.
  • Collaborate on analysis design with computational genomics colleagues.
  • Utilize laboratory automation systems to enhance genomic workflow efficiency.
  • Troubleshoot assays and implement solutions independently.
  • Present findings and recommendations to project and governance teams; contribute to publications and presentations.
  • Mentor junior scientists on experimental rigor and technical execution.

Benefits

  • Eligibility to participate in company-sponsored 401(k) and pension plans.
  • Medical, dental, vision, and prescription drug benefits.
  • Flexible spending accounts for healthcare and dependent care.
  • Life insurance and death benefits.
  • Well-being benefits including employee assistance programs and fitness benefits.
  • Vacation benefits and certain leave of absence benefits.
Full Job Description


Position Overview

We are seeking an experienced scientist to join the Genomic Sciences team in Lilly Genetic Medicine's RNA Therapeutics organization. This team leverages high-throughput approaches to generate data that drives compound selection and lead optimization decisions and enables innovative cross-functional science both within RNA therapeutics and across therapeutic areas.

The successful candidate will join a team of genomics experts who independently identify key scientific questions, design and execute functional genomics experiments to answer them, and integrate results across data modalities to advance compound programs from screening through preclinical development. This role requires close partnership with medicinal chemistry, in vitro pharmacology, in vivo pharmacology, computational genomics, lab automation, and therapeutic area teams-and a scientist who can translate experimental findings into clear recommendations that shape portfolio-facing program decisions.

Key Responsibilities
  • Design and execute NGS-based genomics experiments (e.g., 3' RNA-seq, mRNA-seq, targeted panels, scRNA-seq, spatial transcriptomics, etc.) to support siRNA and ASO compound profiling, selectivity assessment, biodistribution studies, and mechanism-of-action characterization
  • Independently identify scientific questions and develop experimental strategies that advance portfolio programs, applying an end-to-end understanding from assay design through data interpretation
  • Establish and optimize functional genomics workflows at screening scale, including library preparation, multiplexing, QC, and sequencing across NGS platforms
  • Integrate cross-functional and external information-transcriptomic, pharmacologic, structural-to support data-driven decision-making on compound progression and lead selection
  • Collaborate with computational genomics colleagues on analysis design, ensuring experimental parameters (replication, power, controls) support robust statistical inference
  • Leverage laboratory automation systems (e.g., Hamilton, Beckman) to increase throughput and reproducibility of genomics workflows
  • Troubleshoot assay performance, diagnose failure modes, and implement corrective actions with minimal supervision
  • Present scientific findings and recommendations to project teams, governance bodies, and external collaborators; contribute to publications, patents, and conference presentations
  • Mentor junior scientists on experimental design, technical execution, and scientific rigor


Basic Qualifications
  • Ph.D. in genomics, molecular biology, genetics, or a related discipline with a minimum of 2 years of postdoctoral and/or industry experience


Preferred Qualifications
  • Demonstrated track record of independently designing, executing, and interpreting NGS-based functional genomics experiments
  • Experience working on collaborative, cross-functional teams in a pharmaceutical, biotech, or large-scale research environment
  • Strong scientific communication skills with the ability to translate complex genomic data into actionable recommendations for non-specialist stakeholders
  • Exceptional demonstrated ability to collaborate with scientists and business leaders with diverse scientific backgrounds
  • Experience with high-throughput transcriptomic screening workflows in a drug discovery context (e.g., compound profiling, dose-response characterization, off-target assessment)
  • Familiarity with RNA therapeutics biology, including siRNA seed-mediated off-target effects and/or antisense oligonucleotide pharmacology
  • Hands-on experience with spatial transcriptomics (e.g., Xenium, CosMx, MERFISH) and/or single-cell genomics (e.g., 10x Chromium) applied to mechanistic questions in drug development
  • Genomics data analysis skills including differential expression analysis frameworks and visualization of high-dimensional data
  • Experience with laboratory automation platforms for NGS library preparation or sample handling at scale
  • Publication record demonstrating scientific contributions in genomics or functional genomics

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$138,000 - $224,400

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

About Eli Lilly

ICOS Corporation is a biotechnology company that engages in the discovery, development, and commercialization of therapeutic products. It is engaged in the commercialization of treatments for unmet medical conditions, such as benign prostatic hyperplasia, hypertension, pulmonary arterial hypertension, cancer, and inflammatory diseases. It is the developer of a treatment known as Cialis (tadalafil), a product for the treatment of erectile dysfunction through its joint venture with Eli Lilly and Company in North America and Europe. It is also engaged in contract manufacturing services for third parties. It is in a strategic alliance with Solvay Pharmaceuticals, Inc. ICOS Corporation was established in 1989, based in Bothell, Washington. It is currently operated by Eli Lilly and Company.

Eli Lilly Careers

Joining Eli Lilly offers an unparalleled opportunity to become part of a leading global team dedicated to creating a healthier future. As a company revered for its commitment to innovation and leadership in the pharmaceutical industry, Eli Lilly is where your professional journey can flourish. Work You’ll Do At Eli Lilly, we are passionate about transforming patient care and advancing medical innovation. Our team at Eli Lilly is at the forefront of developing groundbreaking solutions in healthcare. By joining us, you will collaborate with some of the brightest minds in the industry, using cutting-edge technology to make real-world impacts. Lead with Innovation and Leadership Eli Lilly stands out in the marketplace by integrating deep industry expertise with robust research and development efforts. We are looking for professionals who are eager to drive change and lead the way in developing therapeutic breakthroughs. Explore Job Opportunities and Growth Eli Lilly offers a variety of career paths, including full-time positions and internships, across multiple functions such as research, marketing, IT, and sales. Whether you are a seasoned professional or a recent graduate, Eli Lilly provides an environment that promotes career growth and learning opportunities. Our commitment to diversity and leadership training ensures that every employee can achieve their potential. Be Part of Our Team Our team at Eli Lilly is committed to excellence and driven by a mission to improve lives. Employees enjoy a supportive culture that values collaboration, creativity, and diversity. We believe that a diverse workforce fosters innovation and helps us better connect with the communities we serve. Benefits and Culture Eli Lilly is dedicated to supporting our employees, offering competitive benefits, wellness programs, and comprehensive health care. Our culture is built on a foundation of respect, integrity, and quality, making Eli Lilly not just a great place to work, but a community to grow with. Networking and Professional Development Eli Lilly encourages continuous professional development and networking. With access to various training programs and mentorship opportunities, employees can enhance their skills and advance their careers. Our leadership is committed to nurturing talent through effective training and development strategies. Join Our Team Discover the exciting job opportunities at Eli Lilly by exploring open positions that match your skills and interests. We are continuously hiring and looking for individuals who are passionate, innovative, and ready to contribute to our mission of making life better for people around the globe. Stay Connected Keep up to date with the latest at Eli Lilly by following our careers blog. Gain insights from industry leaders and get tips on everything from crafting the perfect resume to preparing for your interview. Eli Lilly is not just a company—it's a place where you can make a difference. Explore the positions available and find out how your talents can help change the world. SEARCH ELI LILLY JOBS Stay ahead in your career with Eli Lilly, where innovation, leadership, and a commitment to diversity and growth lead the way to future advancements.
Learn more about Eli Lilly
Size
35,000 employees
Market Cap
$344.2 billion
Industry
Net Income
$6.1 billion
Founded
1876
5 Year Trend
+5.9%
Revenue
$24.5 billion
NASDAQ

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