Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$73K - $110K *

Lead a collaborative nursing team, engaging in quality initiatives and patient care processes. Utilize clinical expertise to assess and implement care plans while promoting a culture of safety and pro...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $170K *

Empower your career by leading global site activation efforts, ensuring compliance and efficiency in clinical trials. Collaborate with cross-functional teams to drive project success and enhance opera...

Today

  •   Less than 5 years exp.  •   Healthcare

$131K - $198K *

Elevate operational efficiency by leading Environmental Services, ensuring quality metrics and SLAs are met while fostering a culture of accountability and collaboration across a diverse, matrixed tea...

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$131K - $198K *

Lead the charge in delivering operational excellence for Environmental Services, overseeing service agreements, performance metrics, and compliance while fostering a culture of engagement and accounta...

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to understanding business needs and delivering technology solutions. As a key liaison between stakeholders and IT, you'll enhance customer experiences and drive project su...

US-AnywhereRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$80K - $95K *

Unlock potential by bridging business needs and IT solutions, ensuring seamless project execution and customer satisfaction. Collaborate with stakeholders to define requirements, manage incidents, and...

US-AnywhereRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$199K - $413K *

Lead the development and execution of innovative global compensation strategies, partnering with stakeholders to enhance employee engagement while ensuring compliance and effectiveness in a dynamic ma...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that's dedicated to managing and expanding government contracts. Lead initiatives to enhance service delivery and drive profitability while ensuring client satisfaction and fostering strat...

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$120K - $160K *

Advance HR technology by leading Workday administration, ensuring optimal system performance, security, and data governance. Collaborate with HR and IT to deliver solutions that enhance business proce...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$90K - $115K *

Drive the financial management for multiple brands, ensuring project alignment and budget integrity while engaging teams and fostering strong client relationships for successful outcomes...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $118K *

Help us support clinical trials by managing site monitoring and ensuring compliance. Utilize your clinical knowledge to protect patient safety and maintain data integrity while thriving in a fast-pace...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$105K - $118K *

Lead the high-quality monitoring of clinical trials, ensuring compliance with regulatory standards while managing site operations, training staff, and protecting participant safety in a fast-paced, dy...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $143K *

Drive the successful execution of complex radiology product projects, ensuring customer satisfaction and operational excellence. Collaborate with cross-functional teams to meet project goals within sc...

US-AnywhereRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $195K *

Unlock potential by leading Workday Financials implementations and optimizations. Collaborate with finance leaders to design scalable solutions, ensuring best practices while guiding clients through d...

US-AnywhereRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$88K - $105K *

Shape HR strategy in support of a manufacturing team by enhancing employee relations, driving change management, and developing talent. Play a pivotal role in fostering a high-performing culture throu...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$122K - $183K *

Analyze and lead the Epic Factory AI Program, driving strategic initiatives and optimizing workflows. Collaborate with IT and business units to enhance performance and usability, ensuring effective pr...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$127K - $171K *

Drive impactful AI deployments, engaging with stakeholders to design and implement scalable solutions. Lead complex projects from discovery to value realization, ensuring success through strategic gui...

US-AnywhereRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $140K *

Pioneer impactful strategies as a Senior Business Value Consultant, driving customer success and revenue growth through compelling business cases and cross-functional collaboration across the entire c...

US-AnywhereRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Partner with us to lead AI Enablement engagements, guiding teams and clients in implementing AI strategies, governance, and training programs while driving impactful adoption and championing AI soluti...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $127K *

Serve as a payroll compliance expert, driving regulatory processes and partnering with R&D teams to enhance payroll software, ensuring compliance with evolving US tax laws affecting thousands of emplo...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$142K - $196K *

Unlock potential by enhancing system reliability and observability for resilient production environments. Collaborate across teams to develop automation and tooling that improves incident response, op...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $159K *

Join a team that's dedicated to enhancing incident management by driving cross-functional coordination and process improvements for privacy incidents, working collaboratively with diverse stakeholders...

US-AnywhereRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $110K *

Lead the charge in managing contracts for utility-scale solar and infrastructure projects. Collaborate with cross-functional teams to ensure compliance, streamline documentation, and support project c...

US-AnywhereRemote

4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$81K - $112K *

Engineer AI-driven solutions automating workflows, enhancing business efficiency. Collaborate with stakeholders to build and deploy secure, effective data science models utilizing advanced AI platform...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Champion the future of brand marketing by driving strategic accounts, navigating complex sales cycles, and delivering high-impact sponsorship solutions tailored to Fortune 1000 companies, while levera...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.