Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$67K - $100K *
Drive category sourcing strategies and supplier relationships to optimize procurement processes, ensuring alignment with organizational standards and delivering value across assigned categories while...
1 week ago
$180K - $220K *
Join a team that's redefining sales in the education sector. Manage the full sales cycle in Texas, collaborating with partners to drive meaningful change in institutions. Your persistence and strategi...
3 weeks ago
$84K - $126K *
Accelerate growth in the cardiovascular ASC market by developing strategic relationships and orchestrating complex opportunities across the U.S. Collaborate with diverse teams to drive customer-focuse...
1 week ago
$220K - $250K *
Unlock potential by driving strategic partner relationships and collaborating across teams to enhance solution development, enabling partners to achieve measurable outcomes while promoting business gr...
Reposted 2 weeks ago
$80K - $90K *
Join a team that's dedicated to optimizing revenue cycle management in healthcare. Lead billing and collections efforts, drive performance, and enhance processes while supporting a high-performing tea...
2 days ago
Complex Claims Advisor | Dedicated Client | East Coast States
$90K - $100K *
Unlock potential by managing complex claims with a focus on legal inquiries and resolutions. Collaborate with clients and experts to deliver innovative solutions while enjoying flexibility and profess...
5 days ago
Principal Technical Partner Relationship Manager
$93K - $159K *
Lead strategic partnerships by managing complex relationships, driving business development, and ensuring effective collaboration across teams to enhance our partner ecosystem and achieve growth objec...
2 weeks ago
Associate Director, Early Patient Engagement & Professional Societies
$145K - $195K *
Unlock patient engagement strategies by integrating insights into drug development. Collaborate with diverse teams to generate evidence, engage with professional societies, and lead initiatives that p...
3 weeks ago
$110K - $130K *
Lead the charge in managing a large-scale FHWA communications program, ensuring effective contract leadership, quality management, and stakeholder engagement across a multidisciplinary team to deliver...
2 weeks ago
Senior Transaction Manager - Industrial
$135K - $170K *
Lead the charge in managing complex real estate transactions, collaborating with brokerage teams to secure optimal deal terms while developing strategic plans that align with client goals and drive op...
2 days ago
$135K - $169K *
Unlock your potential by leading complex design initiatives that define product strategy and influence cross-functional teams. Drive innovation in UX and create impactful solutions while shaping the f...
Reposted 3 weeks ago
Senior Organic Growth Strategist
$100K - $120K *
Lead organic growth strategies for high-value accounts, driving retention and expansion with minimal oversight. Mentor junior strategists, set measurement standards, and support sales efforts while en...
2 weeks ago
$97K - $133K *
Join a dynamic team to drive sales growth and enhance customer relationships. Manage key accounts, collaborate with cross-functional teams, and ensure exceptional service while achieving ambitious sal...
5 days ago
Senior Director of Communications (United States)
$200K - $220K *
Unlock potential by leading the communications strategy across external, internal, and crisis communications. Serve as a trusted advisor to executives, developing narratives and building media relatio...
4 weeks ago
$182K - $198K *
Build and lead a robust Service Management Office to enhance IT operations, ensuring effective governance, accountability, and continuous improvement across a complex 24x7 environment, while fostering...
1 week ago
Senior Product Manager, Atom Engine
$125K - $150K *
Lead the vision and strategy for content development, ensuring quality and usability. Collaborate with stakeholders to align priorities, streamline processes, and enhance the user experience across co...
Reposted 3 weeks ago
$130K - $145K *
Transform the global recruitment function by leading a small team, optimizing processes, and leveraging AI to enhance efficiency and candidate experience while personally closing roles and driving per...
Yesterday
Senior Director, Product, Security and Privacy
$260K - $300K *
Transform product development by ensuring compliance with laws and regulations. Collaborate with cross-functional teams to proactively manage legal risks throughout the product lifecycle, empowering r...
1 month ago
$92K - $115K *
Unlock potential by leading requirements documentation for software projects. Collaborate with stakeholders and technical teams to ensure successful delivery throughout the project lifecycle, while su...
5 days ago
$175K - $210K *
Unlock potential by driving sales and business development for RWD solutions in the life sciences sector. Build relationships with senior stakeholders and leverage market insights to enhance client en...
2 weeks ago
Director, Debt Capital Markets
$150K - $180K *
Join a dynamic team to shape the future of multifamily debt strategy, ensuring asset protection and optimizing financing across acquisitions and refinances while driving investor returns through disci...
Yesterday
$120K - $150K *
Transform enterprise strategies by leading discovery and building account plans that align marketing goals with AI investments, driving growth and success for senior marketing leaders...
2 weeks ago
Manager, Client Strategy & Operations
$100K - $120K *
Join a team that's focused on enhancing client delivery and relationship growth. Drive data-driven strategies and cross-functional collaboration to optimize post-sale operations, ensuring exceptional...
Reposted 1 week ago
$110K - $130K *
Drive strategic sales growth and exceed revenue objectives by building relationships, engaging customers, and managing distributor networks across a multi-state territory, contributing to innovative i...
Reposted 3 weeks ago
$237K - $296K *
Join a team that's driving innovation in oncology by leading clinical development and medical affairs. Collaborate across functions to advance pivotal programs and ensure operational excellence in a f...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.