Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Director, Global Field Operations
$175K - $210K *
Lead global field operations, driving strategy and execution across sales, technical services, and partner functions. Collaborate with senior leadership to optimize pipeline management, forecasting, a...
1 week ago
$80K - $95K *
Drive plant-level sales strategies and cultivate customer relationships to enhance beverage production. Collaborate with teams to identify opportunities and deliver solutions, ensuring consistent prod...
2 weeks ago
$84K - $124K *
Join a passionate team as a Partner Success Manager, driving retention and growth for accounting partners through strategic success planning and tailored growth solutions, while connecting partner nee...
Reposted 3 weeks ago
$110K - $130K *
Oversee the design and development of clinical databases while ensuring project timelines and quality standards are met. Collaborate across teams to provide technical support and mentor team members...
Reposted 5 days ago
$104K - $174K *
Unlock potential by driving client engagement and delivering tailored solutions. Collaborate with cross-functional teams to enhance client experiences, manage complex projects, and present insights to...
3 weeks ago
Associate Director - Philanthropy Operations
$101K - $115K *
Join us in optimizing philanthropy operations by leading strategic initiatives that enhance efficiency, data quality, and staff experience. Collaborate across teams to implement innovative solutions t...
3 weeks ago
$122K - $183K *
Join a team that's driving strategic growth by partnering with leading OEMs. You'll influence product roadmaps, uncover market opportunities, and translate customer insights into scalable solutions fo...
2 weeks ago
Senior Account Manager, Life Sciences (Los Angeles)
$120K - $150K *
Drive customer satisfaction and sales in life sciences by leveraging your expertise to build relationships and execute strategic initiatives with key accounts in academia and industry...
1 week ago
$90K - $110K *
Lead the charge in managing contracts for utility-scale solar and infrastructure projects. Collaborate with cross-functional teams to ensure compliance, streamline documentation, and support project c...
2 weeks ago
Senior Director, Web Strategy and Operations
$160K - $200K *
Shape the future of our web strategy by leading a cross-functional team to optimize user experience, drive demand generation, and enhance web performance. Your expertise will transform our website int...
2 days ago
Senior Director, Client Sales & Insights
$165K - $200K *
Lead the charge in driving commercial activation and revenue growth for a multi-million-dollar portfolio, leveraging strategic insights and AI to enhance client engagement and deliver measurable resul...
2 weeks ago
$95K - $110K *
Shape innovative marketing strategies as a Senior Art Director, leading creative projects that align with client objectives. Collaborate with teams to deliver impactful visual content, driving busines...
Reposted 1 week ago
Director, Professional Services Group
$120K - $150K *
Join a team that's shaping the future of consulting in P&C insurance. Lead client engagements, ensure quality standards, and foster long-term relationships while driving business growth and mentoring...
2 weeks ago
$125K - $150K *
Join us to drive full-cycle sales of an innovative AI platform, engaging top audit and advisory firms. Build relationships, implement strategies, and redefine industry standards while navigating compl...
6 days ago
Regional Sales Director (New York City)
$112K - $143K *
Drive new business growth and expand relationships in your territory. Collaborate with brokers, consultants, and partners to achieve revenue targets while maintaining a strong field presence and deliv...
1 week ago
Senior Director, Commercial Data & Analytics
$190K - $210K *
Unlock data-driven insights as a hybrid leader, balancing hands-on analytics with high-level client strategy. Drive impactful initiatives and foster cross-functional collaboration to deliver valuable...
3 weeks ago
Deal Advisory Director (Healthcare)
$192K - $334K *
Tackle complex healthcare M&A engagements, leading due diligence efforts, and collaborating with clients and teams to drive value. Manage multiple projects while utilizing your expertise to influence...
Reposted 2 weeks ago
$108K - $196K *
Shape the future of healthcare by managing client relationships and optimizing clinical programs. Collaborate with teams to drive client success and ensure alignment with company goals, leveraging dat...
3 weeks ago
Federal Account Executive 4, Direct Sales
$300K - $330K *
Lead the charge in managing complex federal accounts, building relationships with senior leaders, and leveraging sales strategies to deliver tailored solutions that meet customer needs and drive busin...
1 week ago
M3 Sr. Sales Account Executive
$110K - $130K *
Unlock your potential by driving sales growth in the Enterprise ERP market. Engage with diverse clients, manage sales cycles, and foster strategic partnerships to enhance our Digital Transformation pr...
2 days ago
Director, Client Coding Integration
$97K - $145K *
Join a team that's dedicated to ensuring accurate coding and compliance for clinical services, leveraging your expertise to enhance revenue cycle management and contribute to optimal healthcare outcom...
Reposted 6 days ago
Staff Product Manager - Data Products
$182K - $251K *
Join our team to lead the strategy and vision for innovative data products, enhancing our data platform and customer experiences. Collaborate across teams to drive exceptional insights and deliver sol...
Reposted 3 weeks ago
Senior Director, Business System Strategy & Transformation
$180K - $215K *
Lead the charge in transforming supply chain technology strategies, driving innovation and operational excellence across S2P and O2C value streams. Collaborate with cross-functional teams to enhance d...
Reposted 3 weeks ago
Principal Product Designer (Remote)
$160K - $190K *
Lead the charge in shaping user experiences by driving product design strategy, mentoring teams, and collaborating with cross-functional partners to tackle complex enterprise challenges and enhance de...
3 days ago
Strategic Account Executive - East
$125K - $150K *
Transform enterprise cybersecurity with strategic sales expertise, guiding complex decision-making processes and nurturing executive relationships to drive significant business outcomes in high-stakes...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.