Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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$125K - $150K *

Drive growth by hunting new logos and managing full-cycle enterprise deals across a 50-60-account territory. Collaborate with cross-functional teams to shape strategies and turn wins into repeatable m...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Champion results-driven strategies and lead sales professionals by optimizing talent development, enhancing performance, and ensuring operational excellence in line with client goals and compliance st...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Drive the enhancement of Compliance Monitoring and Testing programs, ensuring regulatory alignment and effective risk management. Collaborate with stakeholders to improve operational efficiency and su...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Lead the charge in overseeing financial operations, ensuring accuracy and compliance in accounts payable, vendor management, and budgeting. Collaborate with stakeholders to enhance financial processes...

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$172K - $222K *

Pioneer innovative production techniques as you lead creative projects from concept to delivery. Collaborate with teams to explore AI-driven methods while ensuring exceptional quality across diverse f...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K *

Lead the charge in driving sales for exhibit space and sponsorships, utilizing effective prospecting and negotiation skills to meet annual quotas while managing client relationships and overseeing pro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Lead the charge in optimizing marketing operations to drive developer adoption, pipeline growth, and revenue. Oversee systems, processes, and insights while collaborating with cross-functional teams t...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$195K - $325K *

Join a dynamic team to lead Technology Risk & Compliance initiatives across Global Supply Chain and Operational Technology, driving a risk-aware culture and ensuring compliance with regulatory standar...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$195K - $325K *

Drive a culture of cyber risk accountability by leading Technology Risk & Compliance initiatives across Global Supply Chain and Operational Technology, ensuring alignment with business needs and regul...

Philadelphia, PARemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$163K - $261K *

Shape the future of electrification services by leading operations across the West U.S. region, driving performance excellence, and managing nationwide digital automation initiatives while advancing r...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$156K - $247K *

Contribute to global oncology marketing by developing strategies for ADC launches in advanced cancer settings. Collaborate with cross-functional teams to drive initiatives, enhance customer engagement...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join our dynamic team as a Senior Product Owner, where you'll drive innovative solutions in Finance technology. Collaborate with cross-functional teams to enhance Record to Report processes, ensuring...

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in transforming global Finance technology by partnering with cross-functional teams to deliver innovative Record to Report solutions. Utilize your expertise in Agile product ownership...

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Join a team that drives innovation in early-stage oncology partnerships, ensuring alignment of scientific and corporate goals while managing cross-functional collaboration and governance for impactful...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $175K *

Drive strategic innovation in early-portfolio alliance management, fostering collaborations to advance oncology projects from discovery through clinical stages. Collaborate with diverse teams to ensur...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$152K - $283K *

Unlock your potential in a strategic marketing role focused on enhancing HCP education. Collaborate across teams to deliver impactful educational experiences that align with brand vision and drive mea...

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $170K *

Champion the future of customer engagement by leading lifecycle marketing strategies. Drive retention and loyalty through data-driven personalization across multiple channels, maximizing customer life...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$298K - $340K *

Join a dynamic team to lead strategic statistical programming initiatives, ensuring top-quality deliverables and compliance across diverse clinical trials. Collaborate with cross-functional partners t...

United StatesRemote

Reposted 3 weeks ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive Beam's growth by securing partnerships and expanding market presence. Lead the sales cycle for Beam Notes, engaging key sectors and refining strategies to enhance product-market fit in the US. Y...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $175K *

Join a team that's redefining partner management by owning high-value relationships, driving growth through strategic planning, and collaborating across departments to enhance customer outcomes and re...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Elevate your career by leading the development of high-quality clinical documents for global regulatory submissions. Collaborate with cross-functional teams to ensure data-driven messaging aligns with...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Drive strategic sales initiatives and cultivate key national accounts, ensuring exceptional service delivery and profitable growth through collaboration and tailored solutions. Leverage industry exper...

2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$117K - $189K *

Pioneer global Orexin development programs by driving project management efforts. Partner with the Global Team Leader to oversee cross-functional teams, manage critical activities, and ensure project...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Transform the landscape of dental negotiations by leading strategic partnerships with payers, optimizing contracts, and driving revenue growth through data-driven insights and collaborative execution...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.