Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$85K - $106K *

Analyze and optimize Amazon DSP and paid search campaigns to drive results across Retail Media. Leverage data insights to enhance performance, ensuring KPI excellence while managing fast-paced, multif...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$72K - $97K *

Accelerate progress at clinical trials by supporting regional study delivery, ensuring quality standards, and collaborating with key stakeholders to meet study goals within timelines and budget...

US-AnywhereRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$73K - $110K *

Join a team that's dedicated to providing exceptional pediatric care. As a vital RN, you'll coordinate comprehensive patient care, ensuring safety and therapeutic support while fostering a compassiona...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$164K - $184K *

Lead the charge in driving impactful research studies from conception through publication, combining unique data sources to provide actionable insights for executives. Engage with senior stakeholders...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Drive multi-million ARR growth by expanding enterprise customer relationships and pursuing new business opportunities. Collaborate with cross-functional teams to leverage AI solutions and lead high-le...

US-AnywhereRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $169K *

Accelerate progress at a dynamic startup by driving commercial agreements and managing risk. Collaborate with cross-functional teams to support growth while gaining hands-on experience in a fast-paced...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $140K *

Empower a dynamic team in optimizing revenue cycle services, driving process improvements, and ensuring compliance while fostering client relationships to achieve operational and financial success in...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$88K - $105K *

Lead the charge in managing Self-Perform Operations projects, overseeing all phases from initiation to closeout. Drive operational performance, budget adherence, and team collaboration to ensure succe...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Elevate customer success by guiding clients through their journey, maximizing product value, and fostering strategic partnerships. Collaborate cross-functionally to enhance user experience and drive r...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $210K *

Shape the operational backbone of a dynamic platform by leading investor onboarding, trade operations, and process design. Build scalable systems to support multiple funds while ensuring compliance an...

US-AnywhereRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$136K - $177K *

Transform your career by driving strategic initiatives and business management for a leading financial services organization. Collaborate with senior leadership to enhance operational efficiency and a...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Elevate your career by driving sales success in large enterprises. Own the full sales cycle and build strategic AI and cybersecurity partnerships, expanding our reach in Southern California's competit...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$130K - $160K *

Drive operational excellence by leading a global team to deliver high-quality wellbeing programs. Collaborate with stakeholders to ensure effective execution, maintain standards, and enhance participa...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$91K - $137K *

Support nursing excellence by overseeing staff, enhancing care quality, and ensuring compliance with regulations. Collaborate with management to optimize patient flow and satisfaction while performing...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$153K - $210K *

Transform your career by partnering with teams to drive strategic growth through legal expertise in healthcare contracts, negotiations, and compliance. Collaborate with leadership to optimize performa...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$240K - $300K *

Make your mark at a cutting-edge startup as you lead enterprise sales, building strategic relationships with Fortune 1000 executives while managing complex sales cycles in the AI technology space...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$218K - $256K *

Champion the development of advanced ML systems for identity verification, driving architecture, feature pipelines, and anomaly detection to secure account integrity while leading a team of engineers...

US-AnywhereRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Innovate operational technology infrastructure to enhance manufacturing efficiency, ensuring secure and reliable connectivity across all facilities while leading cross-functional collaboration and str...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$101K - $169K *

Join us in overseeing investment accounting and reporting, ensuring effective internal controls and collaboration with teams and custodians. Drive financial accuracy and compliance in a dynamic remote...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$200K - $230K *

Lead a team that operationalizes advanced AI security solutions for enterprises, ensuring integration and compliance across environments. Collaborate with stakeholders to translate requirements into e...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $100K *

Join a team that's dedicated to transforming healthcare through creativity and strategy. As an Account Supervisor, you'll lead client projects, foster relationships, and mentor junior staff, ensuring...

US-AnywhereRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the charge in driving sales for enterprise accounts, crafting strategies to expand market presence and establishing vital relationships that enhance cybersecurity and AI partnerships in the Ohio...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$120K - $145K *

Lead the evolution of paid social marketing by driving strategy, measurement, and successful execution across major platforms. Collaborate with cross-functional teams to enhance upper-funnel initiativ...

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$139K - $260K *

Champion strategic legal counsel on complex employment matters, guiding business leaders through litigation and regulatory challenges. Influence risk management and policy decisions while collaboratin...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$74K - $125K *

Lead the charge in modernizing a federal agency's data ecosystem. Collaborate with stakeholders to translate needs into actionable features, ensuring backlog readiness and supporting AI initiatives in...

US-AnywhereRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.