Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$79K - $118K *

Transform patient care as a skilled RN in a dynamic emergency department, providing comprehensive treatment for diverse cases. Collaborate with a dedicated team to enhance patient outcomes in a fast-p...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$114K - $171K *

Join a team dedicated to optimizing pharmaceutical care by designing and overseeing medication therapy regimens. Leverage your expertise to support patient education and collaborate with healthcare pr...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's driving the implementation of Oracle Cloud Source to Pay solutions. Leverage your expertise in business processes and technology to lead workshops, configure software, and support c...

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Drive profitable growth by leading strategic account planning and customer engagement. Collaborate with cross-functional teams to enhance customer satisfaction and identify new business opportunities...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the charge in optimizing plant operations, enhancing productivity, and maintaining equipment efficiency. Oversee logistics, employee training, and continuous improvement initiatives while ensurin...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Staffing

$56K - $115K *

Join a dynamic team as a Site Contracts Specialist, where you will negotiate and manage clinical trial agreements. Lead contract discussions, mitigate risks, and collaborate with key stakeholders to e...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to optimizing privacy management processes and compliance technology. This role supports platform administration, user engagement, and operational improvements, ensuring e...

US-AnywhereRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Champion relationships with top mortgage lenders, driving business growth through consultative sales. Leverage Plaid's offerings to enhance loan origination and underwriting, while collaborating with...

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $160K *

Lead the strategy and execution of paid search campaigns, optimizing performance and driving growth. Collaborate with cross-functional teams to enhance conversion rates and mentor team members in best...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Deliver impactful telecom design solutions by overseeing projects, enhancing production efficiency, and collaborating with designers and project managers to meet quality standards and client expectati...

US-AnywhereRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$77K - $85K *

Strategize meaningful partnerships by engaging with community organizations. Drive initiatives in public health, leveraging relationship-building and sales skills to foster collaboration in the health...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Invent and evolve architectural strategies for cloud-native AI platforms at scale. Lead design, deployment, and infrastructure excellence, driving innovation while mentoring teams and shaping technica...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$73K - $110K *

Join a team that's dedicated to delivering exceptional patient care while utilizing your nursing expertise. Engage in quality initiatives, collaborate with diverse healthcare professionals, and promot...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$196K - $292K *

Elevate the quality of software qualifications by leading a high-performing CI/CD engineering team. Drive automation and operational excellence, ensuring readiness for partner environments while colla...

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$175K - $210K *

Shape the future of healthcare technology by leading strategic accounts, driving revenue growth, and fostering executive relationships. Own the sales lifecycle, expand services, and influence cross-fu...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Engage with diverse stakeholders to drive sales initiatives, source new clients, and expand existing accounts. Leverage strong prospecting and strategic relationship-building skills in a fast-paced, c...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $100K *

Lead the charge in expanding our market presence through proactive sales initiatives and strategic growth plans, targeting distribution channels and developing key customer relationships to drive new...

US-AnywhereRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$160K - $225K *

Lead the charge in enhancing inventory and supply chain systems through effective planning, optimization, and analytics. Drive technology choices while mentoring a team to ensure high-quality software...

US-AnywhereRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Media

$90K - $110K *

Champion client success by managing onboarding projects, ensuring smooth implementation, maximizing value delivery, and fostering cross-functional collaboration to drive significant business impact an...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Drive excellence in licensing operations by leading a dedicated team, managing key client portfolios and ensuring high-quality application processes while fostering a culture of accountability and con...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$124K - $280K *

Innovate client operations by leading impactful projects in life, annuity, and group benefits sectors. As a Senior Manager, drive excellence through strategic insights, team coaching, and optimized se...

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$124K - $280K *

Lead the drive for operational excellence in the Insurance sector, utilizing strategic insights to enhance client service. Manage complex projects while coaching teams to innovate and achieve impactfu...

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$125K - $150K *

Grow your career with a leading payroll solution provider, driving enterprise sales and developing client relationships in large organizations while managing complex sales cycles and achieving signifi...

US-AnywhereRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$158K - $326K *

Join a dynamic team to negotiate complex SaaS and cloud agreements, supporting strategic partnerships across multiple functions. Play a key role in driving Pinterest's cloud strategy and operationaliz...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$85K - $112K *

Join a team that's driving innovation in communication technologies. Leverage your sales expertise to expand adoption of our APIs in the Mid-Market segment, collaborating across teams to deliver value...

US-AnywhereRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.