Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Family Office Executive, Private Risk
$125K - $150K *
Join a dynamic team as a subject-matter expert, providing strategic guidance and bespoke insurance solutions for complex multi-generational family offices, while influencing product development and en...
3 days ago
Manager, Customer Success Management
$125K - $155K *
Join a team that's dedicated to enhancing customer success by leading a high-performing group of CSMs. Drive measurable value across a diverse portfolio, ensuring operational excellence and fostering...
2 weeks ago
Senior Director, Growth & Demand Marketing
$277K - $350K *
Elevate your career by leading global demand generation strategies, driving enterprise pipeline growth, and optimizing high-impact ABM programs. Collaborate with cross-functional teams to innovate and...
5 days ago
$150K - $175K *
Lead the charge in optimizing sales force effectiveness through strategic planning, performance management, and process improvement, ensuring productivity and aligning with organizational goals for su...
Reposted 2 weeks ago
Principal Product Manager, Buyer Products
$150K - $180K *
Join a team that's redefining the buyer experience in B2B software. As a Principal Product Manager, you'll lead strategy, drive product delivery, and enhance buyer trust across multiple platforms, ens...
2 days ago
Principal Experience Strategist
$120K - $145K *
Drive user-centered design initiatives by leading research, mapping journeys, and prototyping solutions. Collaborate with teams to validate usability and outcomes while maintaining design practices an...
4 days ago
$120K - $250K *
Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...
2 weeks ago
$214K - $295K *
Reimagine corporate marketing by leading a dynamic team to craft cohesive narratives that resonate with industry leaders and customers. Shape strategies across public relations, social media, and comm...
Reposted 3 weeks ago
$85K - $100K *
Join us to empower senior leaders by managing complex projects, client contracts, and travel arrangements. Your proactive support will enhance team efficiency in a fully virtual environment, fostering...
2 weeks ago
Product Manager - Customer Data Exchange
$86K - $138K *
Lead the strategy and execution of enterprise data exchange products, ensuring secure and standardized data sharing. Collaborate with stakeholders to drive interoperability and maximize business value...
2 weeks ago
Senior Transaction Manager - RETAIL
$100K - $120K *
Contribute to innovative real estate solutions by managing retail transactions, including leases, sales, and acquisitions. Collaborate with clients to align strategies, negotiate terms, and ensure tim...
1 week ago
Senior Director, Software Engineering
$145K - $190K *
Lead the charge in designing and optimizing scalable data pipelines using Azure, PySpark, and Airflow. Collaborate with teams to ensure data quality and performance while mentoring engineers and drivi...
1 week ago
$200K - $300K *
Join a team that's driving revenue growth by cultivating strategic accounts and client relationships. Leverage your sales expertise in solution selling and account management to maximize profitability...
Reposted 3 weeks ago
Digital Product Manager - Data Security
$120K - $193K *
Transform enterprise security by leading product strategy and delivery, focusing on data protection and compliance. Drive innovation through AI integration, ensuring scalable solutions that meet evolv...
1 week ago
Revenue Recovery & Resolutions Strategy Manager
$110K - $130K *
Unlock revenue potential by leading recovery operations, developing strategies, and collaborating across teams to enhance financial performance and resolve complex reimbursement issues. Drive accounta...
3 days ago
Client Manager, Healthcare Acquisition
$102K - $157K *
Unlock potential by driving new customer acquisition in healthcare. Engage C-suite leaders, champion innovative solutions, and lead complex sales cycles across AI and managed services to enhance patie...
2 weeks ago
Regional Director of Clinical Operations
$100K - $120K *
Shape the future of healthcare by leading clinical operations across 3-5 skilled nursing facilities in eastern South Dakota, ensuring regulatory compliance and quality care while managing multiple tea...
Reposted 3 days ago
Senior Manager, Relationship Management
$125K - $145K *
Drive client success and retention by leading a team of managers to ensure exceptional service and satisfaction while leveraging data-driven insights and proactive strategies for account management im...
3 weeks ago
$110K - $130K *
Collaborate with cross-functional teams to enhance Salesforce solutions, driving process improvements and operational excellence. Contribute hands-on to configuration, data management, and user adopti...
3 weeks ago
Senior Scientific Director - Oncology (Medical Affairs & Commercial Medical Education)
$160K - $190K *
Champion the development and oversight of scientific content across diverse therapeutic areas while managing client relationships and brand strategy for multiple accounts, ensuring high-quality and im...
Reposted 2 weeks ago
$180K *
Innovate your career as a Principal Data Engineer, designing cutting-edge data infrastructure and lakehouse solutions. Leverage modern AI tools to enhance performance and quality while collaborating w...
2 days ago
$77K - $130K *
Unlock potential by leading innovative SaaS initiatives that enhance customer experiences and drive business growth. Collaborate with cross-functional teams to shape product strategy, leveraging AI to...
2 weeks ago
Assistant Vice President OR Senior Underwriter - E&S Brokerage - Primary Casualty
$135K - $200K *
Drive profitable growth by underwriting middle market GL accounts in a non-admitted environment. Leverage strong broker relationships, evaluate risks, and mentor junior underwriters while ensuring com...
2 days ago
Enterprise Account Executive - New York or Philadelphia
$130K - $140K *
Lead the charge in managing enterprise partnerships with large educational organizations, driving strategic growth and operational transformation through complex, multi-year agreements and stakeholder...
Yesterday
$115K - $140K *
Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.