Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Account Executive (Vascular) Michigan
$63K - $112K *
Join a team that's dedicated to enhancing client relationships and driving sales growth. Utilize your expertise in medical products to present solutions, ensure customer satisfaction, and collaborate...
1 week ago
Procurement Project Initiatives Manager
$125K - $172K *
Champion procurement excellence by leading strategic initiatives, optimizing processes, and collaborating across functions to drive operational success in a fast-paced, regulated environment. Make a s...
3 weeks ago
Senior Manager, Commercial Partnerships Revenue Accounting and Lifecycle Enablement
$170K - $200K *
Drive the end-to-end commercial partnership lifecycle for Revenue Accounting, ensuring operational readiness, contract execution, and financial accuracy. Collaborate cross-functionally to establish sc...
3 days ago
$112K - $147K *
Drive strategic sales growth for key accounts in the apparel sector. Collaborate effectively with internal teams and external partners to craft tailored business models, optimize product mix, and enha...
Reposted 2 weeks ago
$110K - $130K *
Transform financial operations by leveraging Workday expertise to enhance reporting, payroll, and planning processes. Collaborate with cross-functional teams to deliver scalable solutions and drive co...
Reposted 1 week ago
$130K - $150K *
Accelerate strategic partner growth through visionary sales leadership, driving revenue and pipeline expansion while cultivating dynamic relationships and actionable growth strategies. Own the partner...
Reposted 5 days ago
Client Operations Specialist - Intelligent Operations
$75K - $100K *
Join a team that's dedicated to enhancing client satisfaction and profitability. As a key player, you'll manage client relationships, support sales processes, and ensure seamless communication between...
3 weeks ago
Senior Director, Clinical Operations
$270K - $280K *
Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...
1 week ago
Director, Rebate Product Program
$173K - $200K *
Elevate rebate product strategy by leading development, driving growth, and enhancing operational performance. Collaborate across teams to ensure compliance and deliver measurable outcomes that align...
2 weeks ago
Manager, Market Intelligence & Commercial Analytics
$110K - $130K *
Lead the charge in market intelligence and sales support, bridging teams to drive insights and strategies in U.S. power markets. Collaborate cross-functionally to identify opportunities and enhance cu...
1 week ago
Sr. Director, Sales Systems & Processes
$198K - $298K *
Champion the optimization of Sales systems and processes, driving productivity and strategic initiatives. Collaborate with cross-functional teams to enhance the sales experience and lead a global team...
2 weeks ago
$135K - $160K *
Lead the charge in defining user experience strategy, managing a multi-disciplinary design team to deliver innovative, user-centered digital products while fostering collaboration and high-impact desi...
1 week ago
$110K - $130K *
Lead the charge in leveraging web analytics to drive insightful data solutions, establishing KPIs, implementing tracking strategies, and delivering actionable recommendations for optimizing client onl...
Reposted 3 weeks ago
Senior Director, Delivery Excellence
$207K - $277K *
Lead the charge in enhancing global ERP delivery excellence, driving governance, quality, and continuous improvement across teams. Foster collaboration and optimize resource utilization to ensure pred...
2 weeks ago
Cardiac PET Senior Account Manager
$110K - $130K *
Help us drive the adoption and growth of our innovative cardiac imaging agent through strategic sales and customer education. Collaborate with healthcare partners to exceed sales forecasts and enhance...
Reposted 1 month ago
Director Insights - TV & Streaming
$135K - $150K *
Empower clients by analyzing media investments and delivering actionable insights. Lead a team to enhance media effectiveness, ensuring operational excellence and collaboration across disciplines to d...
2 weeks ago
Global Regulatory Affairs Director - Inflammation and Rare Disease
$189K - $256K *
Join a global team to shape regulatory strategies in biotechnology, supporting product development and lifecycle management in Inflammation and Rare Diseases. Lead regulatory efforts, ensure complianc...
3 weeks ago
Senior Business Systems Leader
$100K - $120K *
Transform business systems by leading ERP initiatives, enhancing integrations, and driving automation. Collaborate with teams to optimize technology solutions that elevate performance and streamline p...
Reposted 3 days ago
Manager, Customer Success - Americas
$110K - $130K *
Elevate customer success in the Americas by leading a growing team of CSMs. Drive adoption, value realization, and customer health while shaping playbooks and strategies for scalable growth. Collabora...
2 weeks ago
Director, Product Ownership - Commercial Products & Platforms
$160K - $190K *
Advance product strategy and innovation by leading cross-functional teams to drive the vision, roadmap, and delivery of shared commercial platforms, ensuring alignment with business priorities and tec...
4 days ago
Senior Product Marketing Manager - Lifecycle & Customer Communications
$135K - $166K *
Drive our end-to-end Lifecycle strategy and customer communications journey, leveraging data and AI to enhance engagement across multiple channels. Collaborate cross-functionally to optimize conversio...
6 days ago
Digital Adoption & Lifecycle Manager
$110K - $130K *
Empower customer success by designing and executing lifecycle programs that enhance adoption, retention, and expansion. Collaborate across teams to create impactful communications and leverage data-dr...
2 weeks ago
Vice President, Enterprise PMO
$247K - $345K *
Unlock potential by leading enterprise-wide strategic initiatives, optimizing program execution, and enhancing technology portfolio management. Drive cross-functional collaboration and operational eff...
2 weeks ago
$77K - $104K *
Engage with customers to build a vibrant community and advocacy program. Drive strategy, foster relationships, and enhance customer experiences through data-driven insights and collaboration across te...
5 days ago
$228K - $285K *
Join us to build internal actuarial capabilities, measuring and pricing economic value across programs. Collaborate with Finance, Clinical, and Commercial teams to develop robust ROI models and perfor...
4 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.