Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$100K *
Drive data-driven decision-making by developing automated reporting solutions. Collaborate with cross-functional teams to enhance enterprise reporting, ensuring accuracy and efficiency while translati...
2 weeks ago
$120K - $145K *
Lead cross-functional teams to develop and execute a strategic product roadmap, integrating market insights and performance metrics to drive customer-centric solutions in the diagnostics and genomics...
2 weeks ago
Director, Global Real-World Evidence & Health Outcomes Scientist, Oncology
$204K - $340K *
Lead the charge in generating impactful real-world evidence to support oncology products, ensuring alignment with market needs and regulatory requirements while collaborating across teams to drive evi...
6 days ago
$100K - $110K *
Take ownership of the month-end close and general ledger, building a robust accounting foundation for a high-growth company. Collaborate with cross-functional teams to ensure accurate financial report...
3 weeks ago
Program Director for Construction Management (Owners Agent)
$157K - $283K *
Lead the charge in delivering large-scale infrastructure projects, managing client relationships, overseeing construction management efforts, and ensuring program success through strategic planning an...
Reposted 3 weeks ago
Strategic Account Executive, SaaS Sales
$90K - $115K *
Transform the sales landscape by owning the full cycle for SaaS solutions, building relationships with key stakeholders in K-12 districts, and driving impactful technology adoption to enhance student...
1 week ago
Director, Commercial Planning & Excellence
$170K - $180K *
Lead the strategic execution of commercial planning and sales coverage, aligning cross-functional teams to drive profitable growth. Oversee territory design, customer segmentation, and annual planning...
2 weeks ago
Change Management Lead - R&D Advisory
$100K - $120K *
Help us drive change management initiatives in life sciences R&D, enhancing efficiency and effectiveness across research, clinical, and regulatory operations while leading stakeholder engagement and a...
1 week ago
$133K - $180K *
Join a team that's redefining member experiences by architecting optimal journeys, bridging operational execution with strategic vision to enhance engagement and satisfaction across all touchpoints...
Reposted today
$170K - $318K *
Join a leading team to shape advanced life insurance strategies, drive high-impact outcomes, and elevate consulting excellence. As a senior executive, you'll mentor talent, innovate processes, and inf...
Reposted 3 days ago
$125K - $169K *
Lead the charge in enhancing customer success initiatives by driving engagement, optimizing processes, and fostering strong relationships. Collaborate with cross-functional teams to ensure exceptional...
Reposted 3 weeks ago
$126K - $171K *
Lead the charge in delivering innovative project management solutions for large law firms. Drive implementations, manage resources, and ensure client satisfaction while navigating complex challenges a...
1 week ago
Director - Product Management, LATAM
$163K - $297K *
Join a dynamic team to shape the future of digital consumer experiences in LATAM. Lead product strategy and execution for innovative e-commerce solutions, driving customer satisfaction and loyalty whi...
2 days ago
Director, Market & Network Strategy
$163K - $214K *
Lead the charge in defining strategic market presence and network design. Drive investment decisions by analyzing demand, competition, and demographics to optimize facility configurations across multi...
Yesterday
Business Development Manager, Enterprise
$135K - $146K *
Innovate strategic partnerships and drive revenue growth in NTN and IoT sectors. Cultivate relationships with global carriers, negotiate agreements, and identify new business opportunities to establis...
5 days ago
Executive Producer - Mainstream, Narrative & New Experiences (Games)
$350K - $500K+*
Lead and innovate in game production, driving strategic initiatives and excellence across a diverse portfolio. Collaborate with teams to deliver high-quality gaming experiences while fostering a cultu...
2 weeks ago
$191K - $305K *
Champion innovative healthcare solutions by leveraging clinical expertise to enhance value-based strategies, drive operational excellence, and foster strategic partnerships for improved member care an...
2 weeks ago
Director, Endowments & Foundations
$150K - $175K *
Transform the future of nonprofit investment strategies by leading client engagement, business development, and team coordination. Drive growth and enhance service delivery for a diverse portfolio of...
1 week ago
Regional Sales Director - Austin
$180K - $215K *
Drive regional success by leading launch execution and building high-performing teams. Foster customer relationships and ensure alignment with corporate goals in a fast-paced, entrepreneurial environm...
4 days ago
$120K - $145K *
Join a dynamic team to lead product strategy and innovation for cutting-edge cloud solutions, driving customer-centric development and measurable growth within the legal technology space. Shape the fu...
Reposted 2 weeks ago
$100K - $125K *
Join a team that's redefining social media marketing by owning paid strategies across Meta and TikTok. Drive creative campaigns, manage substantial budgets, and enhance audience engagement while shapi...
1 week ago
Senior Financial Analyst (Revenue FP&A)
$100K - $120K *
Lead the charge in enhancing revenue forecasting and planning, partnering with Sales and Marketing to deliver actionable financial insights that drive growth and resource allocation across diverse rev...
1 week ago
Vice President of Transformation and Shared Services
$190K - $200K *
Elevate operational excellence by leading transformation initiatives and optimizing Shared Services. Collaborate with senior leaders to drive measurable improvements in productivity, cost efficiency...
4 days ago
$70K - $100K *
Join a team that's dedicated to enhancing financial operations through meticulous month-end close processes, reconciliations, and compliance. Collaborate cross-functionally to drive efficiency and acc...
1 week ago
$119K - $186K *
Execute strategic legal counsel and project management for technology agreements, focusing on healthcare solutions. Collaborate with teams to navigate complex regulatory issues and negotiate high-volu...
4 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.