Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Key Account Manager - Houston, TX
$170K - $205K *
Transform the U.S. sales landscape by driving strategic account plans and fostering relationships in the kidney transplant sector, ensuring optimal product utilization and achieving revenue targets th...
2 weeks ago
$160K - $190K *
Join us as a strategic advisor, providing legal counsel on commercial contracts, AI products, and technology licensing. Collaborate with cross-functional teams to drive proactive solutions and support...
2 weeks ago
Account Based Marketing (ABM) Manager
$100K - $120K *
Join a dynamic team to build and execute innovative ABM programs that engage and grow strategic accounts. Collaborate with sales and marketing to create personalized experiences that drive pipeline an...
1 week ago
Regional Sales Director - Oklahoma City
$180K - $215K *
Elevate regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability and...
4 days ago
Strategic Client Success Manager
$110K - $130K *
Empower customer success by managing strategic accounts, driving growth, and ensuring satisfaction. Build relationships, analyze data, and collaborate cross-functionally to exceed goals and mitigate r...
2 weeks ago
Senior Oncology Account Manager, Birmingham
$150K - $230K *
Drive impactful oncology solutions by building relationships with key stakeholders. Collaborate with internal teams to enhance patient access and exceed performance goals while managing territory reso...
6 days ago
Senior Engagement Manager - Medical Affairs
$210K - $258K *
Unlock your potential as a Senior Engagement Manager, leading complex consulting projects for pharmaceutical clients. Drive strategic medical initiatives, foster client relationships, and mentor teams...
Reposted 3 days ago
Quality Operations Manager (Contract)
$100K - $120K *
Contribute to quality operations initiatives by reviewing study documents, supporting audits, and ensuring compliance with regulatory standards. Collaborate with cross-functional teams to enhance qual...
Today
$71K - $100K *
Drive strategic initiatives by analyzing market trends and performance metrics. Collaborate with cross-functional teams to develop business cases and forecasts, ensuring data integrity and delivering...
1 week ago
$83K - $140K *
Drive strategic financial analysis to optimize R&D expenditures. Collaborate with engineering leaders to enhance reporting frameworks and forecasting models, ensuring accurate budget guidance and impa...
Reposted 3 weeks ago
$83K - $140K *
Lead the charge in financial modeling and forecasting, driving strategic insights and collaborative planning processes across Corporate Finance & Strategy to optimize performance and align financial g...
Reposted 3 weeks ago
Director of Field Operations, Cobrand Card
$125K - $150K *
Shape high-impact growth in retail partnerships by overseeing field operations, driving application volume, and enhancing point-of-sale conversion rates. Collaborate with teams to optimize strategies...
2 weeks ago
Regional Sales Director - Northwest
$180K - $215K *
Unlock regional growth by leading a high-performing sales team, executing launch strategies, and fostering key customer relationships in a dynamic, fast-paced environment. Drive performance and ensure...
4 days ago
Managing Director, Go-to-Market Value Creation
$210K - $250K *
Drive portfolio value creation through strategy execution, leveraging your extensive experience in revenue growth and go-to-market capabilities to lead engagements and mentor GTM teams across technolo...
Reposted 1 week ago
Senior Product Manager, CRM & GTM Systems
$104K - $176K *
Champion the Lead-to-Opportunity domain by driving product strategy, mentoring analysts, and enhancing the GTM tech stack. Influence the roadmap and ensure seamless lead conversion while collaborating...
3 weeks ago
SVP -Business Development Officer -SBA & CRE
$150K - $180K *
Transform your career by driving growth in commercial real estate financing. This role focuses on originating and structuring loans while building strong relationships with clients and industry profes...
2 days ago
$120K - $145K *
Engage partners by driving technical enablement and solution design. Collaborate across teams to empower resellers and integrators, ensuring successful adoption and growth of innovative solutions thro...
3 weeks ago
Growth Sales Executive - Enterprise and Partnerships
$100K - $120K *
Join a team that's transforming patient care access by owning the mid-market and enterprise pipeline, building partnerships, and navigating complex deals to drive impactful growth in a collaborative s...
1 week ago
Sr. Product Operations Manager
$110K - $160K *
Drive your career with a strategic role in Product Operations, partnering with leaders to transform complex challenges into actionable insights, while enhancing cross-functional collaboration and leve...
5 days ago
$138K - $172K *
Empower revenue teams as a Senior Business Systems Analyst, driving efficiency through Salesforce architecture, process design, and actionable data across GTM, Marketing, Sales, and Customer Success o...
Reposted 4 days ago
Key DSO Dental Account Manager
$68K - $113K *
Join a team that's focused on expanding and managing dental provider networks, enhancing relationships with Dental Support Organizations while ensuring compliance and operational efficiency. Drive gro...
Reposted 1 week ago
Director, HR Business Partner - Product and Engineering
$150K - $215K *
Collaborate with senior leaders to design and implement global HR strategies, driving organizational performance and employee engagement while leading a team of HR professionals in a dynamic environme...
1 week ago
$102K - $193K *
Elevate your career by leading a dynamic sales team, driving growth through strategic partnerships, and executing innovative healthcare solutions while achieving personal and team sales goals in a col...
2 days ago
Senior Manager of Customer Success (Enterprise)
$160K - $175K *
Lead strategic initiatives to enhance customer success for high-value enterprise accounts, fostering long-lasting partnerships, driving engagement, and optimizing retention while managing a high-perfo...
Reposted 3 weeks ago
Sr. Account Manager, Client Success
$91K - $145K *
Join a team that's dedicated to enhancing client relationships and driving growth in the pharmaceutical sector. Leverage your expertise to deliver impactful campaigns and ensure client satisfaction wh...
5 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.