Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Sales Director, Original Equipment Manufacturer (OEM) & Defense Primes
$150K - $190K *
Lead a dynamic sales team to drive B2B revenue in defense and unmanned systems. Oversee the sales lifecycle, manage key partnerships, and ensure alignment with engineering and marketing to achieve amb...
2 weeks ago
Director, Data & Distribution Partnerships
$190K - $275K *
Advance the Data & Distribution Partnerships function by innovating and scaling data reseller and distribution models, building commercial arrangements, and leading a team to create revenue-generating...
Reposted 2 weeks ago
Business Development Senior Director
$160K - $200K *
Partner with us to lead transformative business development initiatives in life sciences. Drive revenue through strategic engagement with pharma/biotech partners, managing the full sales cycle and ens...
Reposted 3 weeks ago
$150K - $180K *
Join a team that's redefining renewable energy asset management. Lead the oversight of a diverse portfolio, ensuring optimal performance, compliance, and financial returns while managing third-party o...
2 weeks ago
$110K - $130K *
Champion strategic growth by developing and closing complex SaaS agreements with enterprise financial institutions and fintech platforms, driving market penetration and long-term partnerships across t...
1 week ago
Director of Strategic Accounts - Mid-Market Bay Area
$122K - $187K *
Lead strategic initiatives to drive sales growth and enhance customer relationships within assigned accounts, leveraging your expertise in enterprise software to exceed quotas and deliver tailored sol...
2 weeks ago
$100K - $120K *
Elevate your career by driving product delivery excellence across teams. You'll ensure timely resolution of client requests and bugs, coordinating efforts between Product, Engineering, and Customer Ex...
3 weeks ago
$100K - $120K *
Engage with diverse stakeholders to drive sales initiatives, source new clients, and expand existing accounts. Leverage strong prospecting and strategic relationship-building skills in a fast-paced, c...
3 weeks ago
$120K - $140K *
Transform your career by leading product development initiatives that enhance enterprise reporting and analytics. Collaborate with cross-functional teams to deliver high-quality solutions that meet bu...
5 days ago
Director/Client Partner - Google, Enterprise AI
$180K - $220K *
Transform enterprise AI partnerships by leading strategic growth initiatives, enhancing relationships, and driving revenue across key Google organizations. Leverage your expertise in AI, cloud, and di...
1 week ago
$235K - $291K *
Champion strategic leadership across diverse digital and marketing initiatives, guiding cross-disciplinary teams and fostering client relationships to drive impactful solutions and business growth in...
4 days ago
Regional Sales Director, Territory Sales
$240K - $280K *
Drive sales excellence by leading a high-performing team, executing strategic territory plans, and fostering consultative relationships with key customers to enhance revenue and market share...
5 days ago
$135K - $155K *
Champion product strategy for a leading mobile game, driving growth through LiveOps. Lead a cross-functional team to enhance player engagement, retention, and monetization while balancing immediate pe...
2 weeks ago
$150K - $180K *
Join a team that's shaping global regulatory strategy for rare disease therapies. In this pivotal role, you'll lead submissions and agency interactions across the US, EU, UK, and Japan, driving execut...
3 weeks ago
Director, Talent - Talent Management
$110K - $120K *
Elevate talent management by executing core programs, enhancing employee experience, and driving performance initiatives. Lead cross-functional projects, ensuring accountability and operational contin...
1 week ago
Director 2 ERP Platforms (SAP)
$242K - $363K *
Lead the charge in defining and evolving a global ERP platform strategy, maximizing value through end-to-end transformation of core business processes while ensuring compliance and high performance in...
1 week ago
Product Management Senior Advisor
$113K - $188K *
Champion the development of innovative tools for customer service teams, enhancing agent efficiency and service quality. Collaborate across departments to drive product strategy, leveraging data and u...
Yesterday
$190K *
Lead our product marketing efforts to drive strategy, market growth, and segmentation for innovative public safety software. Collaborate with teams to translate product features into compelling messag...
Reposted 3 weeks ago
$100K - $120K *
Join a dynamic team to drive sales growth in the beauty sector, identifying new opportunities and fostering relationships with key retailers. Collaborate across departments to shape strategies that am...
Reposted 2 weeks ago
Senior Analyst, ALM & Treasury
$88K - $141K *
Empower financial strategies by analyzing interest rate and liquidity risks. Collaborate with stakeholders to enhance capital planning and reporting processes while ensuring compliance with regulation...
2 days ago
Associate Director - Global Communications Intelligence
$127K - $187K *
Unlock potential by transforming data into actionable insights that drive strategic decisions in communications. Collaborate across teams to enhance measurement frameworks and reporting, ensuring impa...
Reposted 2 days ago
$110K - $130K *
Accelerate growth by coaching franchise owners in sales strategies, optimizing processes, and enhancing customer acquisition. Collaborate cross-functionally to develop training programs that foster a...
5 days ago
Enterprise Account Executive, TOLA
$150K - $180K *
Unlock potential by owning the full sales cycle with large enterprise accounts. Drive new business, expand customer relationships, and position solutions as key strategic partners in AI and cybersecur...
3 weeks ago
Director of Property Accounting
$140K - $165K *
Shape the future of property accounting by leading a dynamic team, ensuring timely financial reporting, and driving innovative processes that enhance client trust and operational efficiency across mul...
3 days ago
Regional Sales Director - Birmingham
$180K - $215K *
Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Collaborate cross-functionally to achieve strategic goals in a fast-pace...
4 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.