Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$370K - $490K *
Join a dynamic team to lead enterprise retail sales, driving strategic growth across diverse categories. Coach senior Account Executives, manage complex deals, and build relationships with top merchan...
6 days ago
$110K - $130K *
Unlock potential by owning customer value plans and ensuring adoption, ROI, and product usage for B2B SaaS accounts. Build trusted relationships with stakeholders, drive enablement sessions, and colla...
Reposted 3 weeks ago
Business Data Analyst (Remote)
$100K - $140K *
Transform data into actionable insights by collaborating with leadership to analyze, visualize, and communicate findings. Leverage expertise in business intelligence tools to enhance decision-making f...
2 days ago
Manager, Client Delivery Experience (Output Solutions and Commercialization) - Remote
$105K - $163K *
Lead and manage client-facing teams to deliver high-quality card processing projects, ensuring successful implementations and client satisfaction through effective project management and strategic ove...
2 days ago
Associate Medical Director (RadScience)
$110K - $130K *
Join a dynamic team to lead the creation of impactful scientific content, enhancing medical education and patient outcomes. Collaborate cross-functionally, mentor writers, and drive excellence in heal...
4 days ago
Senior Compliance Analyst - Advertising Review
$85K - $100K *
Champion compliance excellence by reviewing retail communications to ensure adherence to regulations and firm policies. Collaborate with teams to maintain high standards and support organizational goa...
3 days ago
Associate Director, Product Quality
$117K - $189K *
Join a team that's shaping the future of pharmaceutical quality by leading compliance initiatives and building a robust Quality Management System to support innovative therapies in a dynamic, collabor...
1 week ago
Key Account Manager (IN, OH or NC)
$95K - $150K *
Drive success by building strong relationships with key customers, delivering strategic initiatives, and enhancing revenue growth. Collaborate across teams to identify opportunities and implement solu...
2 weeks ago
$160K - $175K *
Shape the future of user experiences by designing intuitive interfaces that empower women in their health journeys. Collaborate across teams to create impactful solutions that merge user insights with...
Reposted 3 weeks ago
Enterprise Account Executive - API
$120K - $300K *
Transform enterprise sales by driving innovative messaging solutions and closing six-figure deals. Leverage your expertise to engage top brands, manage the sales cycle, and foster strong relationships...
3 weeks ago
$126K - $162K *
Drive project success by leading design and construction phases, managing teams, and ensuring client satisfaction in commercial and mission-critical environments. Collaborate with stakeholders to deli...
1 week ago
Senior Business Development Manager (Channel Partnerships)
$125K - $148K *
Drive strategic partner acquisition by generating new business opportunities in workforce payments, focusing on payroll and pension. Collaborate cross-functionally to build a robust pipeline and lead...
1 week ago
Director of Product Management, Data Science
$150K - $180K *
Pioneer a data-driven future by leading product strategy for data science solutions. Drive innovation, oversee development, and ensure alignment with business goals to deliver impactful analytics prod...
2 weeks ago
Partner Manager, Growth Accounts
$160K - $175K *
Champion growth by managing key partner relationships, driving revenue expansion, and ensuring partner success through strategic enablement and collaboration. Leverage your expertise to foster long-te...
2 days ago
$85K - $100K *
Elevate your career by leading cross-functional projects, ensuring timely deliverables and driving process improvements through collaboration and expert project management methodologies...
3 weeks ago
Director, Product - State & Local Government
$176K - $264K *
Champion innovative strategies for State & Local Government, bridging customer needs with product development. Drive revenue growth and enhance customer relationships through industry insights and tai...
Reposted 2 days ago
$130K - $160K *
Drive a structured sales strategy for the US region, achieving targets and creating pipelines through outbound prospecting and tailored solutions while engaging senior stakeholders and maintaining CRM...
1 week ago
Public Sector Major Account Executive
$350K *
Partner with us to drive revenue for key accounts, leveraging your sales expertise to foster relationships, manage complex transactions, and make a real-world impact through innovative tech solutions...
Reposted 3 weeks ago
$90K - $110K *
Develop and implement strategic business initiatives to drive growth, expand market presence, and foster partnerships. Lead cross-functional teams to achieve long-term objectives while identifying new...
4 days ago
Executive Director, Health Economics & Outcomes Research (HEOR)
$246K - $332K *
Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...
5 days ago
$100K - $120K *
Shape the future of project management by leading software implementations, enhancing efficiency, and collaborating with diverse teams. Drive success through strategic planning and effective communica...
2 weeks ago
$134K - $185K *
Reimagine paid search strategy and execution, leading a dynamic team to enhance performance, drive growth, and establish market presence while connecting client objectives with innovative solutions an...
Yesterday
Regional Sales Director (Tampa)
$112K - $143K *
Champion new business growth by building strategic partnerships and expanding market share within your territory. Drive revenue through effective relationship management and a proactive sales strategy...
1 week ago
$95K - $114K *
Join a dynamic team to design and optimize data systems for AI/ML applications, enhancing Navy IT operations. Collaborate with engineers to ensure reliable data processing and support mission-critical...
2 weeks ago
Senior Manager, Global Scientific Communications & Engagement Strategy- Content Lead
$141K - $191K *
Champion high-impact scientific communication strategies, collaborating across Medical Affairs and Commercial. Lead content development, enhance engagement, and drive operational excellence for effect...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.