Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Vice President, Sales Jobs in South Dakota

Sort By: Relevance

$110K - $130K *

Help us lead complex capital projects by overseeing technical and operational management, ensuring timely delivery, and mentoring a talented team for excellence in bulk material handling and construct...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $135K *

Innovate and lead client engagements, driving strategic insights and integrated solutions in a fast-paced healthcare environment while mentoring cross-functional teams towards operational excellence a...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Collaborate with brokers and clients to drive profitable business through expert underwriting of complex accounts. Leverage strategic insights and relationship-building to optimize portfolio performan...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $150K *

Accelerate growth by managing sales strategies across CA and parts of the Midwest. Lead market development efforts, achieve sales goals, and collaborate with cross-functional teams to enhance customer...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$100K - $125K *

Join a team that's redefining enterprise sales by driving new business through consultative strategies. Leverage your expertise to manage complex sales cycles, engage C-suite stakeholders, and exceed...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$147K - $217K *

Lead transformative analytics initiatives in life sciences, driving innovation and client success. Mentor teams, enhance measurement standards, and collaborate cross-functionally to deliver actionable...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$160K - $200K *

Join a team that's driving growth in the dynamic SaaS landscape. Lead strategic sales initiatives, manage top-tier talent, and engage with Fortune 500 clients to deliver impactful solutions that prope...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$162K - $238K *

Design and optimize R&D operations to enhance organizational effectiveness through data-driven insights, collaboration, and governance. Partner cross-functionally to drive continuous improvement and e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$215K - $250K *

Pioneer your career by leading a dynamic sales team focused on Labor and Public Sector markets. Drive growth, mentor talent, and execute strategic initiatives to exceed revenue goals while building im...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$136K - $227K *

Engage in strategic growth initiatives by analyzing market opportunities and driving the execution of Sysco’s Own Brand portfolio strategies. Collaborate across teams to shape and implement impactful...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$94K - $179K *

Lead the charge in managing complex projects from inception to completion, ensuring timely delivery and stakeholder satisfaction while guiding cross-functional teams through the project lifecycle...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Optimize multi-site pharmacy operations by overseeing daily workflows, staffing, and performance metrics. Collaborate with leadership and Pharmacists-in-Charge to ensure compliance and efficiency acro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by leading strategic account management initiatives, driving customer satisfaction and revenue growth through effective relationship building and expansion strategies in a dynamic ent...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$185K - $231K *

Unlock potential by leading regional service delivery, driving growth and operational excellence across multiple territories. Collaborate with diverse teams to enhance customer satisfaction and optimi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$160K - $200K *

Shape the future of product strategy by leading a high-performing team, driving innovation, and ensuring alignment across operations and technology to deliver exceptional customer value and measurable...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Shape high-impact growth in retail partnerships by overseeing field operations, driving application volume, and enhancing point-of-sale conversion rates. Collaborate with teams to optimize strategies...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by leading innovative demand generation strategies that drive pipeline growth and market engagement. Collaborate across departments to optimize campaigns and mentor teams, ensuring al...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$190K - $240K *

Accelerate progress at strategic partnerships in the NAMER region by identifying, onboarding, and managing key partners. Drive revenue growth through collaboration, enablement, and relationship manage...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Unlock potential by driving business growth in the Geo division. Build relationships with engineers and contractors, educate on product offerings, and secure bidding opportunities. Remote work availab...

6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join a team that's driving innovation in cybersecurity by leveraging your technical expertise to support enterprise sales. Engage with top-tier clients, guiding them through complex evaluations and de...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $329K *

Drive operational excellence as you lead sales operations and business planning teams, translating data into strategic decisions that enhance revenue outcomes and foster collaboration across functions...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Shape the future of healthcare technology by leading product management efforts, driving strategy, and delivering innovative data insights solutions. Collaborate with cross-functional teams to enhance...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$105K - $112K *

Drive the success of a dynamic SDR team by shaping outbound sales strategies, mentoring talent, and optimizing lead generation processes. Collaborate with leadership to build a high-performing team th...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $155K *

Champion business development and growth of custom adhesive solutions across North America, focusing on the Bus, Truck, Rail, and Specialty Vehicle markets. Drive customer acquisition and strategic ac...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$90K *

Transform your career by driving new business in public safety. Collaborate with internal teams to build relationships and innovate solutions for Fire, EMS, and Emergency Management agencies in a dyna...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.