Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.
Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.
Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.
Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.
Senior Manager - Site Reliability Engineering (SRE)
$113K - $198K *
Grow your career by leading a high-performing Site Reliability Engineering team, ensuring the stability and performance of digital platforms. Partner with cross-functional teams to drive automation, r...
2 weeks ago
Enterprise Business Development Representative - Central
$100K *
Accelerate progress at building enterprise strategies by driving targeted outreach and engaging with security leaders. Leverage your expertise to generate meaningful pipeline within complex organizati...
4 weeks ago
$75K - $105K *
Join a team that delivers expert technical support to SMBs, guiding them through sales cycles and technical challenges in security and access management, ensuring optimal use of solutions to enhance o...
Reposted 2 weeks ago
$80K - $95K *
Advance program evaluation and data analysis to enhance health system transformation and ensure Veterans receive critical support through effective implementation of the Emergent Suicide Care benefit...
3 weeks ago
AI Engineer / Forward Deployed Engineer (AI Engineering)
$120K - $145K *
Champion the integration of advanced AI solutions into engineering workflows. Drive innovation by designing, developing, and deploying AI-powered tools while collaborating closely with engineering tea...
2 weeks ago
Clinical Research Associate-CRA I/II - FSP
$80K - $95K *
Join a dynamic team as you manage clinical research sites, ensuring compliance and quality throughout all study phases. Build strong relationships, oversee monitoring activities, and contribute to tea...
1 week ago
$78K - $168K *
Shape the future of healthcare by leading a regional Clinical Support team. Drive nursing excellence through recruitment, training, and performance management while fostering an inclusive culture focu...
4 weeks ago
Senior Implementation Operations Specialist
$100K - $120K *
Transform operational challenges into scalable solutions as you analyze data, manage projects, and drive efficiency improvements. Collaborate with cross-functional teams to ensure seamless implementat...
Reposted 1 week ago
Operations Research & Management Lead
$89K - $148K *
Oversee operational frameworks to enhance engineering team performance and efficiency. This cross-functional role combines analytical insights with strategic planning and hands-on leadership to drive...
Reposted 5 days ago
$140K - $270K *
Lead the charge in transforming healthcare workflows with AI solutions, optimizing performance, and collaborating across teams to create scalable systems that enhance clinical and revenue outcomes...
5 days ago
Senior HRIS Systems Manager (Remote)
$110K - $130K *
Join a team that's redefining HR technology! Lead the design and management of our Workday system, collaborating across departments to enhance HR and Payroll processes through innovative solutions and...
1 week ago
$122K - $183K *
Unlock your potential in a dynamic environment, joining a collaborative Emergency Medicine team. Experience diverse care settings, enhance your clinical skills, and contribute to a patient-centered cu...
3 weeks ago
$80K - $95K *
Join a team that's dedicated to delivering exceptional commercial construction projects, from planning through closeout, expertly navigating timelines and budgets while fostering strong client relatio...
Reposted 1 week ago
$85K - $102K *
Engage with stakeholders to lead HR strategies and drive people processes that enhance business performance. Collaborate with teams to implement innovative solutions and foster employee engagement thr...
3 weeks ago
Senior BWRX-300 SRO Operations Training Instructor
$123K - $206K *
Create impactful training solutions by analyzing technical learning needs and improving processes. Stay current with industry trends to support training program effectiveness and foster continuous dev...
Reposted 2 weeks ago
Senior BWRX-300 SRO Operations Training Instructor
$123K - $206K *
Optimize training programs by analyzing learning needs, designing solutions, and ensuring quality oversight. Collaborate with teams to enhance technical training effectiveness while staying informed o...
2 weeks ago
$88K - $105K *
Partner with us to drive HR initiatives, enhance employee engagement, and optimize business outcomes through strategic leadership and collaboration across organizational functions...
Reposted 2 weeks ago
Senior Human Resources Business Partner
$110K - $130K *
Champion strategic HR initiatives that drive organizational design, talent development, and change management. Collaborate with senior leaders to enhance employee experience and align workforce planni...
2 days ago
Procurement & Sourcing Manager
$110K - $130K *
Drive strategic sourcing and vendor negotiations to optimize technology spend, leveraging AI for pricing benchmarks and contract reviews. Collaborate cross-functionally to enhance procurement processe...
5 days ago
$90K - $110K *
Join a team that's dedicated to advancing financial crime analysis by utilizing data-driven methodologies. Work collaboratively to enhance model performance and support compliance across sanctions, fr...
3 weeks ago
$169K - $200K *
Empower growth by serving as a vital HR Business Partner, collaborating with leaders across technical domains to scale high-performing teams while driving people strategies aligned with business goals...
2 weeks ago
$120K - $135K *
Contribute to our finance function by owning daily accounting operations, leading month-end closes, and enhancing systems for efficiency. Engage with leadership to provide actionable insights while ov...
Reposted 2 weeks ago
Registered Nurse (RN) - Levine Children's Urology Outpatient Clinic
$73K - $110K *
Transform your nursing career by providing compassionate, comprehensive care to pediatric patients in a dynamic outpatient setting. Collaborate with a dedicated team across multiple locations to enhan...
Reposted 1 week ago
Account Director Retail - Southwest
$110K - $130K *
Champion growth in the retail sector by driving account development and sales. Leverage strong customer relationships to enhance satisfaction and profitability while effectively managing your sales pi...
Reposted 2 weeks ago
$65K - $120K *
Pioneer innovative solutions by collaborating with clients to enhance operational efficiency and effectiveness through technology consulting, ensuring alignment with strategic goals and optimizing use...
3 weeks ago
What types of $100K+ jobs can I find in North Carolina?
Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.
Which North Carolina cities have professional job opportunities?
Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.
Does Ladders list jobs paying $100,000 or more?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.
How can I search for jobs in North Carolina?
Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.