Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$143K - $198K *

Elevate your career by designing and maintaining robust enterprise network infrastructures. Collaborate with cross-functional teams to optimize performance, ensure security, and support critical appli...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$75K - $129K *

Join a team that's redefining data solutions by architecting scalable data pipelines and cloud platforms. Leverage your expertise to deliver reliable data for strategic initiatives and operational exc...

US-AnywhereRemote

6 days ago

  •   5 - 7 years exp.  •   Transportation

$100K - $120K *

Join us to lead the full sales cycle of our innovative TMS system, driving growth in the mental health sector. Collaborate with founders, engage with clinical customers, and shape our market strategy...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Drive business analysis by gathering requirements, documenting processes, and validating Salesforce solutions to enhance customer satisfaction and operational efficiency through effective stakeholder...

US-AnywhereRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$90K - $124K *

Unlock potential by leading customer advocacy initiatives, driving content strategy, and managing high-volume production of case studies and testimonials. Collaborate with cross-functional teams to en...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$83K - $114K *

Join our dynamic team as you deliver compassionate dialysis nursing services. Collaborate with professionals in a fast-paced environment, utilizing your critical thinking skills to ensure patient safe...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$114K - $171K *

Grow your career with a dynamic healthcare team focused on delivering comprehensive midwifery services in both inpatient and outpatient settings. Enjoy collaborative support while expanding your exper...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Transform relationships with customers or partners by developing tailored sales plans and fostering trust, aimed at exceeding sales goals while acting as a thought leader in a fast-paced, complex envi...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Transform the public sector sales landscape by leading a dynamic team to exceed targets, foster relationships, and drive growth through strategic engagement. Your expertise will empower success and in...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$62K - $100K *

Advance data analysis of health encounters to ensure compliance with SLAs while driving continuous process improvement. Collaborate across teams to enhance data usability and support regulatory initia...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Unlock advanced analytics to drive strategic improvements in consumer products, ensuring high performance in risk and profitability through actionable insights and partnership across teams for optimal...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $150K *

Engineer transformative solutions by integrating cutting-edge APIs into enterprise systems. Collaborate closely with clients to deploy production software efficiently while leveraging modern AI tools...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$95K - $115K *

Shape operational excellence by leading a dynamic team in materials planning and execution for Engineered-to-Order manufacturing, ensuring timely delivery and optimal resource utilization while foster...

6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$180K - $258K *

Drive sales growth by strategizing expansion and nurturing key client relationships. Leverage data insights to optimize territory performance and collaborate with cross-functional teams to deliver tai...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $258K *

Advance business growth by driving strategic sales across regions, nurturing client partnerships, and orchestrating multi-functional solutions to enhance value and performance in the biopharmaceutical...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Optimize property performance through strategic maintenance leadership, driving safety culture and sustainability. This impactful role necessitates technical expertise and frequent travel to ensure ex...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$68K - $103K *

Oversee the planning and execution of multi-center studies, ensuring compliance and successful outcomes. Collaborate with researchers, manage staff, and evaluate data to drive impactful health-related...

Today

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Contribute to the success of pharmaceutical programs by managing client relationships, overseeing daily operations, and driving performance. Collaborate cross-functionally to ensure program execution...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$79K - $118K *

Champion patient care by implementing evidence-based practices and collaborating with healthcare teams. Engage in continuous improvement initiatives while ensuring safety and effective communication w...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$99K - $232K *

Advance your career by leading contract lifecycle management projects that drive innovation and optimize processes. You'll guide teams, enhance operations, and empower clients with data-driven solutio...

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$99K - $232K *

Lead the charge in transforming contract lifecycle management to drive innovation and optimize processes. Leverage data analytics and technology to enhance client operations while mentoring teams and...

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Champion innovative sales strategies and drive B2B growth in the fintech sector. As a key team member, excel in consultative selling while building strong relationships and harnessing internal experti...

US-AnywhereRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$125K - $150K *

Accelerate solution design for scalable, cloud-based SaaS platforms, engaging with stakeholders to translate complex needs into actionable strategies while fostering innovation in higher education tec...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$82K - $114K *

Transform clinical applications by assessing needs, troubleshooting solutions, and implementing upgrades. Collaborate with teams to enhance workflows and provide expert support, ensuring optimal funct...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Analyze and optimize workforce management strategies across multiple business lines, translating complex forecasts into actionable capacity plans and financial models while collaborating with executiv...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.