Explore $100K+ Jobs in North Carolina

Discover professional opportunities across North Carolina with Ladders, a job site focused on roles paying $100,000 or more. From established business centers to growing regional markets, the state offers opportunities for experienced professionals seeking their next career move.

North Carolina’s Professional Job Markets

Charlotte is a major hub for banking, financial services, and corporate leadership. The Research Triangle—including Raleigh, Durham, and Chapel Hill—has opportunities across technology, life sciences, healthcare, education, and research. Other cities and regions also support careers in manufacturing, logistics, energy, and professional services.

Roles for Experienced Professionals

Browse senior and specialized openings in areas such as software and technology, finance, healthcare, engineering, sales, operations, and executive leadership. Listings vary by employer and location, so review each posting for its responsibilities, qualifications, work arrangement, and compensation details.

Find Your Next North Carolina Opportunity

Use Ladders to explore vetted professional jobs with salaries of $100,000 or more. Search by job title, employer, or location, and compare openings across North Carolina to find roles that align with your experience and career goals.

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$150K - $180K *

Transform healthcare administration by leading enterprise-wide HIMS operations, ensuring compliance and driving performance improvement across a multi-state network while fostering an engaged workforc...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$125K - $150K *

Drive growth in the employer vertical by building relationships, closing deals, and developing sales strategies to optimize clinical solutions, improving outcomes and cost efficiency for employee popu...

US-AnywhereRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in building a cohesive AI-driven revenue engine, harmonizing Sales, Marketing, and Customer Success through strategic direction, data modeling, and robust use of HubSpot for execution...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Develop and execute strategies for university relations and early career talent acquisition, fostering partnerships and innovative programs to attract and nurture the next generation of talent for a l...

6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$79K - $118K *

Join a team that champions patient wellness by conducting RN-led Medicare visits, ensuring comprehensive care assessments, and promoting preventive services to enhance long-term health outcomes for di...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Lead the charge in financial planning and analysis, driving strategic initiatives and cross-functional collaboration to enhance decision-making and operational effectiveness in a mission-driven enviro...

US-AnywhereRemote

6 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Champion the management of clinical trials by ensuring protocol compliance, overseeing site interactions, and leading the clinical project team to mitigate risks and enhance patient safety, data integ...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$91K - $175K *

Join a team that solves complex data challenges, developing insights from multiple sources to support business decisions. You'll mentor peers and lead the implementation of advanced reporting solution...

US-AnywhereRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$160K - $235K *

Lead the charge in securing K-12 district accounts, driving full-cycle sales from prospecting to closing. Engage with district leaders, navigate procurement processes, and maintain a robust pipeline a...

US-AnywhereRemote

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$67K - $95K *

Transform your career by engaging in diverse corporate legal tasks, contract negotiations, and compliance work. This role emphasizes collaboration, adaptability, and proactive support across legal div...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $95K *

Shape the future of compensation management by leading a dynamic team, ensuring compliance, and enhancing service delivery. Drive optimal performance through coaching and process improvements while ma...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$168K - $240K *

Transform your expertise into a platform that empowers engineering teams. Drive scalable, secure infrastructure solutions that enhance operational efficiency and the development of innovative financia...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Develop innovative applications for critical power and building electrification while understanding customer demands. Drive product development, support validation, and enhance market competitiveness...

Reposted today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$136K - $160K *

Elevate operations through AI-driven automation to enhance incident management, streamline ticket resolution, and optimize service health with self-healing observability, all while collaborating acros...

US-AnywhereRemote

Reposted today

  •   Less than 5 years exp.  •   Hospitality & Recreation

$100K - $120K *

Lead the charge in driving complex sales within mid-market organizations, influencing hiring strategies and compliance. Own the full sales cycle, build strong pipelines, and engage with multiple stake...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$79K - $118K *

Provide compassionate nursing care in a pediatric behavioral health unit, coordinating comprehensive patient care and ensuring a safe, therapeutic environment through evidence-based practices and effe...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Join a dedicated team as a compassionate RN, providing comprehensive care in a pediatric behavioral health unit. Collaborate with multidisciplinary professionals to ensure safe, therapeutic environmen...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by collaborating with cross-functional teams to enhance business operations, streamline processes, and drive value through effective analysis and documentation. Your expertise will...

US-AnywhereRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Transform the supply chain landscape by leading client engagements across retail, focusing on strategy optimization, performance improvement, and system implementation while inspiring and mentoring ju...

4 weeks ago

  •   5 - 7 years exp.  •   Business Services

$138K - $187K *

Partner with us to elevate community engagement through strategic outreach and relationship building. You'll develop and execute local initiatives, plan impactful events, and represent our interests a...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$90K - $170K *

The Account Executive in-territory for Justworks is responsible for managing the full sales cycle, including prospecting, building relationships, and closing deals within the Orange County area. This...

US-AnywhereRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Pioneer growth by developing business strategies, expanding key relationships, and navigating new markets. Collaborate across teams to enhance sales performance and drive profitability while shaping t...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Join a team that's committed to enhancing data security by leading insider risk investigations. In this hands-on managerial role, you'll develop detection strategies and mentor your team while ensurin...

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$106K - $284K *

Lead application development initiatives, ensuring quality standards in healthcare IT. Collaborate with diverse teams to define requirements and implement solutions that profoundly impact patient care...

US-AnywhereRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $185K *

Champion the growth of new business within the Army by building relationships, shaping solutions, and leading contract execution while managing a diverse portfolio and driving customer satisfaction th...

US-AnywhereRemote

Today

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    Listings may include senior and specialized roles in technology, finance, healthcare, engineering, sales, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Which North Carolina cities have professional job opportunities?question toggle

    Opportunities can be found in Charlotte, Raleigh, Durham, Chapel Hill, and other North Carolina cities and regions. Search by location to see current openings.

  • Does Ladders list jobs paying $100,000 or more?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Check individual postings for compensation information and role details.

  • How can I search for jobs in North Carolina?question toggle

    Search Ladders by job title, employer, or North Carolina location, then review listings for qualifications, responsibilities, work arrangement, and compensation.