Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Account Director Jobs in South Dakota

Sort By: Relevance

$200K - $250K *

Drive transformative enterprise sales by pioneering BGO's AI-first strategy. As the first seller, you'll build a robust pipeline, shape the sales playbook, and establish BGO as a leader in innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$133K - $177K *

Join a team that's transforming healthcare by driving strategic account growth and solving complex identity challenges. Collaborate with cross-functional teams to deliver measurable outcomes and enhan...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $175K *

Join a team that's driving transformation in insurance technology by leading complex SaaS programs. You'll ensure delivery excellence, manage risks, and enhance client confidence while shaping the fut...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$234K - $322K *

Transform global revenue accounting and order-to-cash processes in a dynamic healthcare environment. Lead a high-performing team, ensuring compliance with U.S. GAAP and driving systems improvements fo...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $160K *

Drive client success in our lab network by managing relationships, ensuring renewals, and identifying growth opportunities. Collaborate across teams to enhance processes and improve client experiences...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Pioneer in search strategy, driving optimization across paid, organic, and AI channels. This role collaborates with cross-functional teams to enhance visibility, engagement, and customer acquisition t...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $235K *

Drive product excellence by owning the lifecycle and security of high-performance client SaaS platforms hosted on AWS. Lead a dedicated team to optimize operations, ensure compliance, and deliver seam...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$274K - $371K *

Develop and lead early phase clinical strategies for oncology candidates, ensuring design and execution of clinical trials. Collaborate with internal teams and external experts to drive innovative dru...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Join a team that's shaping the future of innovation in cancer research by leading financial planning and commercialization efforts to support strategic growth and decision-making across an impactful o...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Hospitals & Medical Centers

$90K - $120K *

Accelerate progress at driving revenue through strategic pipeline development and multi-touch outreach. Collaborate with marketing to uncover opportunities and engage with elite engineers, ensuring a...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$220K - $250K *

Lead enterprise security operations and resilience, driving cyber risk strategy and innovation. Collaborate cross-functionally to embed security principles, modernize defenses, and build high-performi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$75K - $109K *

Advance the future of Building Information Modeling by leading BIM strategies, ensuring model quality, and mentoring teams. Drive innovation through technology initiatives and enhance project delivery...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$62K - $112K *

Transform member engagement by proactively addressing concerns, coordinating solutions, and enhancing satisfaction. Collaborate with cross-functional teams to drive improvements and ensure a seamless...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$170K - $205K *

Drive the integration and growth of a newly acquired business, overseeing P&L, client relationships, and operations. Collaborate with teams to ensure seamless transition and performance against revenu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$88K - $100K *

Champion the growth of financial advisor teams by shaping impactful marketing strategies. As a strategic partner, you will guide planning, enhance accountability, and drive measurable outcomes, while...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Take ownership of data governance by facilitating alignment among stakeholders, executing metadata management, and coaching teams on sustainable stewardship practices. Drive data quality and complianc...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Transform the supply chain landscape by leading procurement and subcontracting efforts, ensuring compliance with federal regulations while driving efficiency and innovation in support of critical defe...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$100K - $120K *

Unlock client success by managing complex Risk Management accounts, coordinating teams, and driving service delivery. Collaborate with clients to ensure expectations are met and explore opportunities...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Drive the future of finance data analysis by ensuring accuracy and usability of financial data. Collaborate with finance and data teams to enhance reporting processes and validate data integrity for i...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $235K *

Lead the charge in developing robust backend applications, driving complex projects from design to launch. Collaborate across teams, mentor junior engineers, and tackle architectural challenges to enh...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Drive sales success by managing the full cycle of large enterprise information security deals. Build key relationships, leverage AI tools, and exceed targets to propel company growth across multiple i...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Advance your career by leading a global team in revenue recognition and technical accounting. Drive policy development, ensure compliance, and partner with cross-functional teams to optimize financial...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$85K - $113K *

Engage with finance leaders to drive growth in our client base, leveraging your FinTech expertise. Collaborate with a dynamic sales team to refine strategies and exceed sales quotas while promoting in...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $150K *

Empower strategic partnerships to enhance product distribution and revenue. Collaborate with cross-functional teams to drive integration, manage agreements, and optimize partner relationships for grow...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$85K - $100K *

Join a team that's driving growth in premium roofing products by building strategic relationships with key industry players, expanding market share, and providing innovative solutions while managing a...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.